You are currently viewing a new version of our website. To view the old version click .

Bioengineering, Volume 12, Issue 8

August 2025 - 111 articles

Cover Story: Osteoarthritis (OA) affects millions of people worldwide, with its prevalence increasing significantly as individuals age. However, the specific mechanisms by which aging leads to cartilage degeneration remain unclear. Despite decades of research, no in vitro model has successfully captured cartilage aging in a physiologically relevant manner. In this study, we address this gap by developing a reproducible system that utilizes human serum from elderly donors to simulate cartilage aging. After treatment with the aged serum, the cartilage constructs display key phenotypes associated with aging, including loss of the extracellular matrix, increased inflammation, and decreased regenerative capacity. This innovative platform provides a valuable, human-relevant tool for identifying the underlying factors driving cartilage aging and for accelerating the development of targeted therapies for OA. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (111)

  • Article
  • Open Access
763 Views
12 Pages

A Time-Series Approach for Machine Learning-Based Patient-Specific Quality Assurance of Radiosurgery Plans

  • Simone Buzzi,
  • Pietro Mancosu,
  • Andrea Bresolin,
  • Pasqualina Gallo,
  • Francesco La Fauci,
  • Francesca Lobefalo,
  • Lucia Paganini,
  • Marco Pelizzoli,
  • Giacomo Reggiori and
  • Ciro Franzese
  • + 4 authors

Stereotactic radiosurgery (SRS) for multiple brain metastases can be delivered with a single isocenter and non-coplanar arcs, achieving highly conformal dose distributions at the cost of extreme modulation of treatment machine parameters. As a result...

  • Article
  • Open Access
789 Views
10 Pages

Introducing Holographic Surgical Navigation in Pediatric Wilms’ Tumor Patients: A Feasibility Study During Total Nephrectomy

  • Nick T. de Groot,
  • Jasper M. van der Zee,
  • Guus M. J. Bökkerink,
  • Annemieke S. Littooij,
  • Caroline C. C. Hulsker,
  • Cecilia E. J. Terwisscha van Scheltinga,
  • Cornelis P. van de Ven,
  • Ruud C. Wortel,
  • Aart J. Klijn and
  • Marc H. W. A. Wijnen
  • + 2 authors

Wilms’ tumor is a common pediatric renal malignancy. In selected cases, nephron-sparing surgery (NSS) may be employed as part of the surgical approach. To prevent positive margins, optimal understanding of the tumor–kidney edge is essenti...

  • Article
  • Open Access
801 Views
17 Pages

Multimodal imaging techniques have the potential to enhance the interpretation of histology by offering additional molecular and structural information beyond that accessible through hematoxylin and eosin (H&E) staining alone. Here, we present a...

  • Article
  • Open Access
1,268 Views
18 Pages

Enhancing Clinical Decision Support with Adaptive Iterative Self-Query Retrieval for Retrieval-Augmented Large Language Models

  • Srinivasagam Prabha,
  • Cesar A. Gomez-Cabello,
  • Syed Ali Haider,
  • Ariana Genovese,
  • Maissa Trabilsy,
  • Nadia G. Wood,
  • Sanjay Bagaria,
  • Cui Tao and
  • Antonio J. Forte

Retrieval-Augmented Generation (RAG) offers a promising strategy to harness large language models (LLMs) for delivering up-to-date, accurate clinical guidance while reducing physicians’ cognitive burden, yet its effectiveness hinges on query cl...

  • Review
  • Open Access
1,359 Views
28 Pages

The accumulation of blood toxins, including urea, uric acid, creatinine, bilirubin, p-cresyl sulfate, and indoxyl sulfate, poses severe health risks for patients with renal failure. Effective removal strategies are essential to mitigate complications...

  • Article
  • Open Access
765 Views
12 Pages

Evaluating SnapshotNIR for Tissue Oxygenation Measurement Across Skin Types After Mastectomy

  • Saif Badran,
  • Sara Saffari,
  • William R. Moritz,
  • Gary B. Skolnick,
  • Amanda M. Westman,
  • Mitchell A. Pet and
  • Justin M. Sacks

Accurate monitoring of mastectomy skin flap (MSF) perfusion is critical, especially in patients with darker skin pigmentation at higher risk of misdiagnosed tissue ischemia. Near-infrared spectroscopy (NIRS) devices, such as SnapshotNIR, offer real-t...

  • Article
  • Open Access
1 Citations
1,533 Views
15 Pages

A High-Fidelity mmWave Radar Dataset for Privacy-Sensitive Human Pose Estimation

  • Yuanzhi Su,
  • Huiying (Cynthia) Hou,
  • Haifeng Lan and
  • Christina Zong-Hao Ma

Human pose estimation (HPE) in privacy-sensitive environments such as healthcare facilities and smart homes demands non-visual sensing solutions. Millimeter-wave (mmWave) radar emerges as a promising alternative, yet its development is hindered by th...

  • Article
  • Open Access
795 Views
22 Pages

Mapping Emerging Scientific Trends in Chronic Skin Disorders Using Machine Learning-Based Bibliometrics

  • Nicoleta Cirstea,
  • Andrei-Flavius Radu,
  • Delia Mirela Tit,
  • Ada Radu,
  • Gabriela S. Bungau,
  • Laura Maria Endres and
  • Paul Andrei Negru

Chronic dermatologic diseases are characterized by pathophysiologic complexity and the existence of many unmet patient management needs that can contribute to treatment failure, with poor adherence being a major issue. This study aims to identify key...

  • Article
  • Open Access
1,319 Views
13 Pages

Biomechanical Characterisation of Gait in Older Adults: A Cross-Sectional Study Using Inertial Sensor-Based Motion Capture

  • Anna Letournel,
  • Madalena Marques,
  • Ricardo Vigário,
  • Carla Quintão and
  • Cláudia Quaresma

The ageing of the global population, especially in developed countries, is driving significant societal changes. In Portugal, demographic data reflect a marked increase in the ageing index. Understanding gait alterations associated with ageing is ess...

  • Review
  • Open Access
3 Citations
6,952 Views
42 Pages

Artificial Intelligence in Sports Biomechanics: A Scoping Review on Wearable Technology, Motion Analysis, and Injury Prevention

  • Marouen Souaifi,
  • Wissem Dhahbi,
  • Nidhal Jebabli,
  • Halil İbrahim Ceylan,
  • Manar Boujabli,
  • Raul Ioan Muntean and
  • Ismail Dergaa

Aim: This scoping review examines the application of artificial intelligence (AI) in sports biomechanics, with a focus on enhancing performance and preventing injuries. The review addresses key research questions, including primary AI methods, their...

of 12

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354Creative Common CC BY license