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Bioengineering
Special Issues
Recent Advances in Biomimetic Approaches for Targeted Nanomedicine
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Recent Advances in Biomimetic Approaches for Targeted Nanomedicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1240

Special Issue Editor

Dr. Junqing Wang

E-Mail Website
Guest Editor
School of Pharmaceutical Science (Shenzhen), Sun Yat-Sen University, Guangzhou 510275, China
Interests: lipoprotein mimetics; constrained peptides; long-circulating scaffold proteins

Special Issue Information

Dear Colleagues,

This Special Issue of Bioengineering focuses on the potential of biomimetic approaches in targeted nanomedicine. Despite the proven potential of nanomedicines like liposomes and mRNA-containing lipid nanoparticles in clinical applications, their development often confronts challenges like poor biocompatibility, immunogenicity, instability, and the complexity of integrating multi-therapeutic functionalities. Using a biomimetic strategy, which involves reverse engineering from biology to nanomedicine, can potentially overcome these hurdles. These systems, encompassing platforms such as albumin-based nanoparticles, virus-like particles, nanodiscs, extracellular vesicles, cell membrane-derived nanocarriers, and polysaccharides, are lauded for their targeted delivery, minimized side effects, and enhanced therapeutic outcomes. This Special Issue emphasizes advancements in biomimetic techniques in diagnosing and treating various diseases such as cancer, infectious diseases, and cardiovascular and genetic diseases.

Potential topics include, but are not limited to:

  • Albumin-based nanoparticles: exploring their role in overcoming the hurdles of traditional nanomedicines.
  • Virus-like particles in targeted nanomedicine: a biomimetic approach to enhanced drug delivery.
  • Nanodiscs: leveraging nature's design for improved therapeutic outcomes in cancer therapy.
  • The role of extracellular vesicles in nanomedicine: from natural functionality to tailored therapeutics.
  • Cell membrane-derived nanocarriers: bridging the gap between nature and nanotechnology for drug delivery.
  • Polysaccharides in biomimetic nanomedicine: harnessing natural materials for improved biocompatibility and stability.
  • Overcoming immunogenicity in nanomedicines: lessons from biomimetic strategies.
  • The future of mRNA-containing lipid nanoparticles: biomimetic enhancements for genetic disease therapies.
  • Tackling infectious diseases with biomimetic nanomedicine.
  • The role of bio-inspired nanotechnologies in diagnosis and treatment.

Dr. Junqing Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • targeted nanomedicine
  • biomimetic approaches
  • reverse engineering
  • nanodiscs
  • extracellular vesicles

Published Papers (1 paper)

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Research

20 pages, 5103 KiB  
Article
Molecular Dynamics and In Vitro Studies Elucidating the Tunable Features of Reconfigurable Nanodiscs for Guiding the Optimal Design of Curcumin Formulation
by Yongxiao Li, Wanting Xu, Xinpei Wang, Ruizhi Lai, Xiaohui Qiu, Zekai Zeng, Zhe Wang and Junqing Wang
Bioengineering 2024, 11(3), 245; https://doi.org/10.3390/bioengineering11030245 - 29 Feb 2024
Viewed by 999
Abstract
In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We explore APA-ND interactions with an emphasis on curcumin encapsulation, [...] Read more.
In this study, we advance our exploration of Apolipoprotein A-I (apoA-I) peptide analogs (APAs) for their application in nanodisc (ND) assembly, focusing on the dynamic conformational characteristics and the potential for drug delivery. We explore APA-ND interactions with an emphasis on curcumin encapsulation, utilizing molecular dynamic simulations and in vitro assessments to evaluate the efficacy of various APA-ND formulations as drug carriers. The methodological approach involved the generation of three unique apoA-I α-11/3 helical mimics, resulting in fifteen distinct APAs. Their structural integrity was rigorously assessed using ColabFold-AF2, with particular attention to pLDDT and pTM scores. Extensive molecular dynamics simulations, covering 1.7 μs across 17 ND systems, were conducted to investigate the influence of APA sequence variations on ND stability and interactions. This study reveals that the composition of APAs, notably the presence of Proline, Serine, and Tryptophan, significantly impacts ND stability and morphology. Oligomeric APAs, in particular, demonstrated superior stability and distinct interaction patterns compared to their monomeric counterparts. Additionally, hydrodynamic diameter measurements over eight weeks indicated sequence-dependent stability, highlighting the potential of specific APA configurations for sustained colloidal stability. In vitro study successfully encapsulated curcumin in [AA]3/DMPC ND formulations, revealing concentration-dependent stability and interaction dynamics. The findings underscore the remarkable capability of APA-NDs to maintain structural integrity and efficient drug encapsulation, positioning them as a promising platform for drug delivery. The study concludes by emphasizing the tunability and versatility of APA-NDs in drug formulation, potentially revolutionizing nanomedicine by enabling customized APA sequences and ND properties for targeted drug delivery. Full article
(This article belongs to the Special Issue Recent Advances in Biomimetic Approaches for Targeted Nanomedicine)
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