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Bioengineering
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Innovations in Nerve Regeneration
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Innovations in Nerve Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1927

Special Issue Editor

Dr. Yiu Yan Leung

E-Mail Website
Guest Editor
Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
Interests: orthognathic surgery; trigeminal nerve repair; maxillofacial imaging; temporomandibular disorder
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue is dedicated to highlighting the ground-breaking advancements in the field of nerve regeneration, focusing on the latest technologies, methodologies, and biomaterials that have shown promising results in the treatment and management of peripheral nerve injuries and neurodegenerative diseases.

Peripheral nerve injuries and neurodegenerative conditions have long been challenging the medical community due to their complex etiology and lack of effective treatment options. As a result, researchers have been exploring novel approaches to address these debilitating conditions, focusing on the regeneration and repair of damaged nerve tissue. This Special Issue aims to highlight the recent developments in tissue engineering, drug delivery systems, and stem cell therapy that have shown promising outcomes in nerve regeneration. The use of biocompatible and biodegradable materials, such as hydrogels, nanofibers, and scaffolds, has been reported to support the growth of new nerve tissue and promote functional recovery after injury.

This Special Issue serves as a comprehensive overview of the current state of research in the field of nerve regeneration, shedding light on the innovative technologies and approaches that have the potential to revolutionize the treatment and management of peripheral nerve injuries and neurodegenerative diseases. As the field continues to evolve, it is expected that these innovations will contribute significantly to improving the quality of life of millions of patients affected by these debilitating conditions.

Dr. Yiu Yan Leung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Review

18 pages, 1293 KiB  
Review
Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries
by José Fábio Lana, Annu Navani, Madhan Jeyaraman, Napoliane Santos, Luyddy Pires, Gabriel Silva Santos, Izair Jefthé Rodrigues, Douglas Santos, Tomas Mosaner, Gabriel Azzini, Lucas Furtado da Fonseca, Alex Pontes de Macedo, Stephany Cares Huber, Daniel de Moraes Ferreira Jorge and Joseph Purita
Bioengineering 2024, 11(5), 461; https://doi.org/10.3390/bioengineering11050461 - 6 May 2024
Viewed by 539
Abstract
Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading to significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, and surgical interventions, often fall short in fully addressing the underlying pathophysiology and [...] Read more.
Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading to significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, and surgical interventions, often fall short in fully addressing the underlying pathophysiology and resultant disabilities. Emerging research in the field of regenerative medicine has introduced innovative approaches such as autologous orthobiologic therapies, with bone marrow aspirate (BMA) being particularly notable for its regenerative and anti-inflammatory properties. This review focuses on the potential of BMA to modulate inflammatory pathways, enhance tissue regeneration, and restore neurological function disrupted by SCI. We hypothesize that BMA’s bioactive components may stimulate reparative processes at the cellular level, particularly when applied at strategic sites like the sacral hiatus to influence lumbar centers and higher neurological structures. By exploring the mechanisms through which BMA influences spinal repair, this review aims to establish a foundation for its application in clinical settings, potentially offering a transformative approach to SCI management that extends beyond symptomatic relief to promoting functional recovery. Full article
(This article belongs to the Special Issue Innovations in Nerve Regeneration)
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14 pages, 1056 KiB  
Review
Innovations in Peripheral Nerve Regeneration
by Ting Chak Lam and Yiu Yan Leung
Bioengineering 2024, 11(5), 444; https://doi.org/10.3390/bioengineering11050444 - 30 Apr 2024
Viewed by 473
Abstract
The field of peripheral nerve regeneration is a dynamic and rapidly evolving area of research that continues to captivate the attention of neuroscientists worldwide. The quest for effective treatments and therapies to enhance the healing of peripheral nerves has gained significant momentum in [...] Read more.
The field of peripheral nerve regeneration is a dynamic and rapidly evolving area of research that continues to captivate the attention of neuroscientists worldwide. The quest for effective treatments and therapies to enhance the healing of peripheral nerves has gained significant momentum in recent years, as evidenced by the substantial increase in publications dedicated to this field. This surge in interest reflects the growing recognition of the importance of peripheral nerve recovery and the urgent need to develop innovative strategies to address nerve injuries. In this context, this article aims to contribute to the existing knowledge by providing a comprehensive review that encompasses both biomaterial and clinical perspectives. By exploring the utilization of nerve guidance conduits and pharmacotherapy, this article seeks to shed light on the remarkable advancements made in the field of peripheral nerve regeneration. Nerve guidance conduits, which act as artificial channels to guide regenerating nerves, have shown promising results in facilitating nerve regrowth and functional recovery. Additionally, pharmacotherapy approaches have emerged as potential avenues for promoting nerve regeneration, with various therapeutic agents being investigated for their neuroprotective and regenerative properties. The pursuit of advancing the field of peripheral nerve regeneration necessitates persistent investment in research and development. Continued exploration of innovative treatments, coupled with a deeper understanding of the intricate processes involved in nerve regeneration, holds the promise of unlocking the complete potential of these groundbreaking interventions. By fostering collaboration among scientists, clinicians, and industry partners, we can accelerate progress in this field, bringing us closer to the realization of transformative therapies that restore function and quality of life for individuals affected by peripheral nerve injuries. Full article
(This article belongs to the Special Issue Innovations in Nerve Regeneration)
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13 pages, 1226 KiB  
Review
Fabrication of Artificial Nerve Conduits Used in a Long Nerve Gap: Current Reviews and Future Studies
by Ryosuke Kakinoki, Yukiko Hara, Koichi Yoshimoto, Yukitoshi Kaizawa, Kazuhiko Hashimoto, Hiroki Tanaka, Takaya Kobayashi, Kazuhiro Ohtani, Takashi Noguchi, Ryosuke Ikeguchi, Masao Akagi and Koji Goto
Bioengineering 2024, 11(4), 409; https://doi.org/10.3390/bioengineering11040409 - 22 Apr 2024
Viewed by 567
Abstract
There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the conduit, capillary extension and Schwann cell [...] Read more.
There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the conduit, capillary extension and Schwann cell migration from both nerve stumps, and, finally, axon extension from the proximal nerve stump. Artificial nerves connecting transected nerve stumps with a long interstump gap should be biodegradable, soft and pliable; have the ability to maintain an intrachamber fibrin matrix structure that allows capillary invasion of the tubular lumen, inhibition of scar tissue invasion and leakage of intratubular neurochemical factors from the chamber; and be able to accommodate cells that produce neurochemical factors that promote nerve regeneration. Here, we describe current progress in the development of artificial nerve conduits and the future studies needed to create nerve conduits, the nerve regeneration of which is compatible with that of an autologous nerve graft transplanted over a long nerve gap. Full article
(This article belongs to the Special Issue Innovations in Nerve Regeneration)
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