Animal Models of Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Huntington's disease (HD), are currently affecting more than 20 million people globally. As medicine advances and life spans extend, the number of ND cases is expected to surge quickly in the near future. To date, there is no effective therapy that can cure, halt, or even delay pathological progression, which has posed tremendous financial and emotional burdens to patients’ families.

One possible reason for this dilemma is the scarceness of animal models that can accurately mimic disease pathogenesis, or the inappropriate interpretation of the results from animal models. Animal models are essential tools for preclinical research; NDs are generally initiated via the interaction of various cell types as well as central nerve system dialogue with the peripheral system, underscoring research at the organism level. As gene edition technology advances and clinical genetics findings increase, more ND animal models have been generated in the past decades, therefore bringing us more insights into ND pathogenesis.

This Special Issue aims to collect the latest research concerning ND animal model creation, new pathogenesis mechanism findings from ND animals, and artificial intelligence-based integrative analyses of previous models.

Authors are invited to submit original research articles, as well as opinion and review papers.

We look forward to receiving your contributions.

Dr. Xiangyu Guo
Guest Editor

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• neurodegenerative diseases
• Alzheimer's disease
• amyotrophic lateral sclerosis
• Parkinson's disease
• Huntington's disease
• neuroscience
• animal models
• pathogenesis