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Biology
Special Issues
Anti-cancer Agents and Their Function Mechanism
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Anti-cancer Agents and Their Function Mechanism

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 442

Special Issue Editor

Prof. Dr. Haiyan Tian

E-Mail Website
Guest Editor
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
Interests: medicinal chemistry; active substance; new drugs

Special Issue Information

Dear Colleagues,

Complex Natural products are an important part of modern drugs and are an important source of new drug research and development. For example, taxol from plants, Dactinomycin D from microorganisms, etc., all have strong anti-tumor activity and unique mechanisms of action, and are the star molecules of anti-tumor drugs. Modern technologies such as artificial intelligence, molecular networks, and genome mining have been widely applied in natural drug discovery, greatly improving the efficiency and accuracy of researchers in discovering new anti-tumor drugs from natural resources. In addition, with the development of molecular biology, some new target discovery techniques have also been widely applied to study the mechanisms of naturally active molecules, adding new vitality to the development of natural anti-tumor drugs.

This Special Issue aims to summarize some of the newest advances related to the discovery of new anti-cancer natural molecules and their function mechanism. Original research papers and reviews focusing on new natural product discovery, especially those with novel structures and potent anti-cancer activities, that target and study the functional mechanism of natural bioactive molecules are welcome.

Prof. Dr. Haiyan Tian
Guest Editor

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Keywords

  • anti-cancer
  • natural products
  • bioactive molecules
  • targets
  • peptides
  • marine organism
  • plants
  • microorganism

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Published Papers (1 paper)

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Research

25 pages, 1225 KiB  
Article
Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa
by Fatiha Seglab, Mazen Abou Assali, Thoraya AlYafei, Hassan Hassan, Diana C. G. A. Pinto, Safaa Baydoun, Asmaa A. Al Thani and Abdullah A. Shaito
Biology 2024, 13(9), 687; https://doi.org/10.3390/biology13090687 - 2 Sep 2024
Abstract
Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. viscosa has been shown to have anticancer effects against various cancers, but its effects against lung cancer have been under limited investigation. At the same [...] Read more.
Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. viscosa has been shown to have anticancer effects against various cancers, but its effects against lung cancer have been under limited investigation. At the same time, I. viscosa is rich in terpenoids whose anti-lung cancer effects have been poorly investigated. This study aimed to examine the potential anticancer properties of methanolic and aqueous extracts of stems and leaves of I. viscosa and its terpenoid-rich fraction against human lung cancer A549 cells. Results showed that the methanolic extracts of I. viscosa had significantly higher polyphenol and flavonoid content and radical scavenging capacity than the aqueous extracts. In addition, leaves methanolic extracts (IVLM) caused the highest reduction in viability of A549 cells among all the extracts. IVLM also reduced the viability of human ovarian SK-OV-3, breast MCF-7, liver HepG2, and colorectal HCT116 cancer cells. A terpenoid-rich I. viscosa fraction (IVL DCM), prepared by liquid-liquid separation of IVLM in dichloromethane (DCM), displayed a substantial reduction in the viability of A549 cells (IC50 = 27.8 ± 1.5 µg/mL at 48 h) and the panel of tested cancerous cell lines but was not cytotoxic to normal human embryonic fibroblasts (HDFn). The assessment of IVL DCM phytochemical constituents using GC-MS analysis revealed 21 metabolites, highlighting an enrichment in terpenoids, such as lupeol and its derivatives, caryophyllene oxide, betulin, and isopulegol, known to exhibit proapoptotic and antimetastatic functions. IVL DCM also showed robust antioxidant capacity and decent polyphenol and flavonoid contents. Furthermore, Western blotting analysis indicated that IVL DCM reduced proliferation (reduction of proliferation marker Ki67 and induction of proliferation inhibitor proteins P21 and P27), contaminated with P38 MAP kinase activation, and induced the intrinsic apoptotic pathway (P53/BCL2/BAX/Caspase3/PARP) in A549 cells. IVL DCM also reduced the migration of A549 cells, potentially by reducing FAK activation. Future identification of anticancer metabolites of IVL DCM, especially terpenoids, is recommended. These data place I. viscosa as a new resource of herbal anticancer agents. Full article
(This article belongs to the Special Issue Anti-cancer Agents and Their Function Mechanism)
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