Gut Immunity, Inflammation, and Allergy

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1684

Special Issue Editor


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Guest Editor
Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si 54810, Jeollabuk-do, Republic of Korea
Interests: inflammatory disease; cancer; neurodegenerative diseases; pharmacology; biochemistry

Special Issue Information

Dear Colleagues,

Gut immunity refers to the immune responses that occur within the digestive system. The digestive system has barriers and immune functions to prevent penetration and neutralize harmful substances such as external bacteria, viruses, and parasites. The gut barrier acts as a protective lining, preventing the infiltration of harmful substances into the internal environment of the digestive system. If inflammation becomes chronic or persistent, it can lead to various diseases and conditions. Chronic inflammation is associated with conditions such as arthritis, cardiovascular diseases, endometriosis, and colitis, among others.

An allergy is an abnormal immune response in which the immune system mistakenly identifies typically harmless substances (allergens) as harmful invaders. When an allergic person comes into contact with an allergen, the immune system releases chemicals such as histamine, leading to an inflammatory response. This can result in symptoms like sneezing, itching, rashes, and difficulty breathing.

Gut immunity, inflammation, and allergy are interconnected, and imbalances in gut immunity can contribute to the development of allergies and inflammation. Maintaining a healthy gut with a balanced diet, proper hydration, and other lifestyle factors can help support gut immunity and reduce the risk of inflammation and allergies. Additionally, medical or nutraceutical treatments and the avoidance of allergens are crucial for managing allergies effectively.

The Special Issue aims to bring together original papers that highlight significant advances in the fields of "Gut Immunity, Inflammation, and Allergy". We welcome submissions that provide novel insights into the complex interplay between gut immunity, inflammation and allergies and the development of their potential therapeutic agents.

Dr. Mi-hee Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut immunity
  • inflammation
  • allergy
  • nutrients
  • therapeutic agents
  • molecular biology

Published Papers (2 papers)

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Research

12 pages, 1313 KiB  
Article
Metabolic Profiling Changes Induced by Fermented Blackberries in High-Fat-Diet-Fed Mice utilizing Gas Chromatography–Mass Spectrometry Analysis
by Jae Young Park, Ha-Rim Kim, Seung-Hyeon Lee, Sang-Wang Lee, Hong-Sig Sin, Seon-Young Kim and Mi Hee Park
Biology 2024, 13(7), 511; https://doi.org/10.3390/biology13070511 - 9 Jul 2024
Viewed by 344
Abstract
The aim of this study was to investigate the metabolic changes associated with the anti-obesity effects of fermented blackberry extracts in the liver tissues of high-fat-diet-fed mice using mass spectrometry-based metabolomics analysis. C57BL/6J mice were divided into eight groups: normal-diet-fed mice, high-fat-diet-fed mice, [...] Read more.
The aim of this study was to investigate the metabolic changes associated with the anti-obesity effects of fermented blackberry extracts in the liver tissues of high-fat-diet-fed mice using mass spectrometry-based metabolomics analysis. C57BL/6J mice were divided into eight groups: normal-diet-fed mice, high-fat-diet-fed mice, high-fat diet treated with blackberry extract, high-fat-diet mice treated with blackberry fermented by L. plantarum, and high-fat diet with blackberry fermented by L. brevis. After 12 weeks, the high-fat-diet group exhibited a greater increase in liver weight compared to the control group, and among the groups, the group administered with blackberry fermented with L. plantarum showed the most pronounced reduction in liver weight. As the primary organ responsible for amino acid metabolism, the liver is crucial for maintaining amino acid homeostasis. In our study, we observed that the levels of several essential amino acids, including isoleucine and valine, were decreased by the high-fat diet, and were recovered by administration of blackberry extract fermented with L. plantarum. Our results demonstrated the potential of blackberry extract fermented with L. plantarum as a functional material for metabolic disorders by restoring some of the amino acid metabolism disturbances induced by a high-fat diet. Full article
(This article belongs to the Special Issue Gut Immunity, Inflammation, and Allergy)
18 pages, 10693 KiB  
Article
Mesenteric Lymphatic B Cells Migrate to the Intestine and Aggravate DSS-Induced Colitis via the CXCR5–CXCL13 Axis
by Yu Zhang, Zhe Wu, Qinghe Zhao, Yaming Liu, Qing Huang, Menglei Zhang, Shuolei Li, Di Wang, Na Li, Yujing Chi and Yulan Liu
Biology 2024, 13(5), 322; https://doi.org/10.3390/biology13050322 - 6 May 2024
Viewed by 998
Abstract
The pathogenesis of inflammatory bowel disease (IBD) is still unknown. Mesenteric lymphatics (MLs), which are closely related to the intestine in both anatomy and physiology, have been suggested to be involved in IBD. In the present study, we aim to investigate the effects [...] Read more.
The pathogenesis of inflammatory bowel disease (IBD) is still unknown. Mesenteric lymphatics (MLs), which are closely related to the intestine in both anatomy and physiology, have been suggested to be involved in IBD. In the present study, we aim to investigate the effects of ML immune cells on IBD and explore the potential associated mechanisms. Acute colitis was induced in rats using dextran sulfate sodium salt (DSS). Mesenteric lymphangiogenesis, ML stenosis, and dilation were observed, with an increased proportion of MLB cells in DSS-induced colitis rats. The adoptive transfer of B cells isolated from ML (MLB) was employed to investigate their effects on colitis. MLB cells derived from DSS-induced colitis rats exhibited a higher propensity to migrate to the intestine. The proportion of colonic T cells was altered, along with the aggravated colitis induced by the adoptive transfer of MLB cells derived from DSS-induced colitis rats. RNA sequencing revealed increased Cxcr5 expression in MLB cells from colitis rats, while real-time PCR indicated an upregulation of its ligand Cxcl13 in the colon of colitis rats. These findings suggest that MLB cells may migrate to the intestine and aggravate colitis. In summary, colonic T cells respond to MLB cells from colitis rats, and MLB cells aggravate DSS-induced colitis via the CXCR5–CXCL13 axis. Full article
(This article belongs to the Special Issue Gut Immunity, Inflammation, and Allergy)
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