Metabolic Interactions between the Gut Microbiome and Host
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 3565
Special Issue Editors
Interests: intestinal microbiome; probiotics; intestinal barrier; metabolome; intestinal innate immunity
Interests: nutrition; gut microbiota; IBD; NAFLD; intestinal barrier function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The symbiotic relationship between the gut microbiota and the host imparts metabolic, immune, and intestinal protective functions to healthy individuals. This interaction is largely determined by factors such as nutritional status and lifestyle habits. Diet is a major driver in shaping the gut microecosystem, which provides selective growth advantages for specific species of bacteria. Long-term dietary intervention can regulate the composition and function of intestinal microbiota in both humans and animals. Simultaneously, the metabolic activity of gut microbes also has an important impact on host health and the metabolic phenotype of the host, which can be beneficial or harmful. Gut microbiota imbalance is closely related to the occurrence and development of chronic metabolic diseases, such as diabetes, obesity, inflammatory bowel disease, cardiovascular disease, depression, tumor, and so on. Therefore, it is vital to reveal the strain specificity that produces microbial metabolites, which will facilitate the identification and discovery of strains or specific metabolites for diseases for therapeutic purposes.
This Special Issue focuses on “Metabolic Interactions between the Gut Microbiome and Host” and welcomes the submission of original research and review articles focusing on the causal relationship and its intrinsic mechanisms between the gut microbiome and the host; however, research on new methods and technologies employed for studying key bacteria and their specific molecules, microbial heterogeneity, that will help us to understand the gut microbiota in depth is also welcome. This Special Issue will enlighten readers about new discoveries, advances, and developments in microbiome-related disease therapeutics.
Dr. Weiwei Wang
Dr. Yun Ji
Guest Editors
Manuscript Submission Information
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Keywords
- gut microbiome
- host
- metabolome
- microbial heterogeneity
- biomolecules
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Generalized ketogenic diet induced liver impairment and reduced probiotics abundance of gut microbiota in rat
Ge Song1, Li Wang1, Dan Song1, Yongwei Wang1, Weiwei Wang1*
1Academy of National Food and Strategic Reserves Administration, Beijing 100037 China;
Abstract
Ketogenic diet is becoming an assisted treatment to control weight, obesity and even type 2 diabetes. However, there was no scientific proof supporting that the ketogenic diet was absolutely safe and sustainable. In this study, Sprague Dawley (SD) rats were fed different ratios of fat to carbohydrate under the same apparent metabolizable energy level to evaluate the effects of ketogenic diet on healthy subjects. The results showed that ketogenic diet could relatively sustain body weight, enhanced the level of serum alanine aminotransferase (ALT), and serum alkaline phosphatase (SAP), more moderate lipoidosis, and milder local non-specific inflammation in liver, compared with the high carbohydrate diet. In addition, the abundance of probiotic strains such as Lactobacillus, Lactococcus and Faecalitalea were reduced in ketogenic diet of rats while the abundance of pathogenic strains such as Anaerotruncus, Enterococcus, Rothia and Enterorhabdus were increased in both ketogenic diet and high carbohydrate diet. This study suggests that ketogenic diet can lead to impairment of liver function and changed composition of gut microbiota in rat, which to some extent indicated the unsafety of consuming ketogenic diet.
Keywords: ketogenic diet; lipoidosis; gut microbiota; apparent metabolizable energy
2. Benefits of polyphenols on gut microbiota and intestinal immune systems
Chenxu Zhao a,b,1, Ge Song b,1, Yuyu Chen b,c, Wentao Qi b,*, Yong Wang b,*
a College of Food Science and Engineering, Central South University of Forestry and Technology, National Engineering Research Center for Rice and Byproduct Deep Processing, Changsha 410004, China
b Academy of National Food and Strategic Reserves Administration, Beijing 100037, China
c School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
Abstract
Polyphenols are widely available in the diet, which have antioxidant, anti-inflammatory, anti-obesity, and many other benefits. Polyphenols regulate the health conditions via intestinal flora of the host. The interaction between polyphenols and gut flora would further influence intestinal immune system and gut barrier functions. Dietary polyphenols may promote health through interactions with the gut microbiota, modulation of the immune system, gut barrier function in various signal pathways. This review addresses the digestion, transportation, metabolites, and bio-function of polyphenols and the sources of polyphenols in food. The potential applications, future development, and challenges of polyphenols obtained from food are also explored.
