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Biology
Special Issues
Emerging Roles for Proteolytic Enzymes in Physiological Homeostasis
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Emerging Roles for Proteolytic Enzymes in Physiological Homeostasis

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1800

Special Issue Editor

Dr. Gonzalo Izaguirre

E-Mail Website
Guest Editor
College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: proteases; serpins; coagulation factors; proprotein convertases; furin; regulation of virus cell entry by proteases

Special Issue Information

Dear Colleagues,

The hydrolysis of peptide bonds catalyzed by proteinases is a reaction that is central to physiology and homeostasis. The catalyzed breakup or degradation of proteins is a common control mechanism that is involved in countless regulatory systems. Networks of proteases that work in cascades of proteolytic events and that are precisely balanced by inhibitors constitute robust and effective control systems regulating a wide variety of events at the cellular or systemic levels. These include blood coagulation, immune responses, hormonal balance, blood pressure, embryonic development, intracellular proteolysis–proteosome, cell death, wound healing, protein secretion and transport, cell signaling, etc. Proteases are highly diverse and can be classified based on their localization in bodily fluids or their association with cell compartments and their catalytic mechanism, which involves different nucleophiles. The MEROPS peptidase database catalogs hundreds of different proteases, including serine, cysteine, aspartic, threonine, and metallo proteinases. The disregulation of the precise balance of proteolytic activity leads to diseased states that can be the subject of therapeutic intervention with protease inhibitors. Infectious diseases with bacteria or viruses also involve regulatory proteases. This Special Issue entitled “Emerging Roles for Proteolytic Enzymes in Physiological Homeostasis” intends to compile a representative and updated survey of examples showing how the homeostatic balance is maintained by the elegant and precise work of proteases and their inhibitors.

We are pleased to invite you to participate in this Special Issue by submitting expert-level contributions describing how proteases control physiology and homeostasis.

This Special Issue aims to present a modern collection of examples of how proteases control physiology and homeoatasis.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: biochemistry, medicine, animal and plant physiology, bacteriology, cell biology, immunology, molecular biology, parasitology, systems biology, and microbiology.

I look forward to receiving your contributions.

Dr. Gonzalo Izaguirre
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • proteinases
  • peptide cleavage
  • proteolytic degradation
  • regulatory proteases
  • protease inhibition
  • proteolytic activity

Published Papers (1 paper)

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Research

15 pages, 3380 KiB  
Article
Corin Deficiency Diminishes Intestinal Sodium Excretion in Mice
by Xiabing Gu, Kun Wang, Wenguo Li, Meiling He, Tiantian Zhou, Meng Liu, Qingyu Wu and Ningzheng Dong
Biology 2023, 12(7), 945; https://doi.org/10.3390/biology12070945 - 1 Jul 2023
Cited by 2 | Viewed by 1454
Abstract
Sodium excretion, a critical process in sodium homeostasis, occurs in many tissues, including the kidney and intestine. Unlike in the kidney, the hormonal regulation of intestinal sodium excretion remains unclear. Atrial natriuretic peptide (ANP) is a crucial hormone in renal natriuresis. Corin is [...] Read more.
Sodium excretion, a critical process in sodium homeostasis, occurs in many tissues, including the kidney and intestine. Unlike in the kidney, the hormonal regulation of intestinal sodium excretion remains unclear. Atrial natriuretic peptide (ANP) is a crucial hormone in renal natriuresis. Corin is a protease critical for ANP activation. Corin and ANP are expressed mainly in the heart. In this study, we investigated corin, ANP, and natriuretic peptide receptor A (Npra) expression in mouse intestines. Corin and ANP expression was co-localized in enteroendocrine cells, whereas Npra expression was on the luminal epithelial cells. In Corin knockout (KO) mice, fecal Na+ and Cl− excretion decreased compared with that in wild-type (WT) mice. Such a decrease was not found in conditional Corin KO mice lacking cardiac corin selectively. In kidney conditional Corin KO mice lacking renal corin, fecal Na+ and Cl− excretion increased, compared to that in WT mice. When WT, Corin KO, and the kidney conditional KO mice were treated with aldosterone, the differences in fecal Na+ and Cl− levels disappeared. These results suggest that intestinal corin may promote fecal sodium excretion in a paracrine mechanism independent of the cardiac corin function. The increased fecal sodium excretion in the kidney conditional Corin KO mice likely reflected an intestinal compensatory response to renal corin deficiency. Our results also suggest that intestinal corin activity may antagonize aldosterone action in the promotion of fecal sodium excretion. These findings help us understand the hormonal mechanism controlling sodium excretion the intestinal tract. Full article
(This article belongs to the Special Issue Emerging Roles for Proteolytic Enzymes in Physiological Homeostasis)
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