Biological Foundations of Psychiatric Disorders

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1085

Special Issue Editor


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Guest Editor
1. Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
2. Department of Neurosciences, University of Wyoming, Laramie, WY 82071, USA
Interests: psychiatric disorders; molecular mechanisms; animal models; therapeutic discovery; genetic associations; sex differences; protocols; methods; behavioral studies; stress-related phenotypes

Special Issue Information

Dear Colleagues,

The study of psychiatric disorders requires a multidisciplinary approach, drawing from molecular genetics, neurobiology, cellular biology, and behavioral science. New tools, including genome-wide association studies, single-cell RNA sequencing, and animal models, are enabling detailed insights into the cellular and molecular bases of these complex conditions. These approaches are crucial for identifying biomarkers, uncovering sex-specific differences, and assessing novel therapeutic targets.

To support these advancements, we invite submissions for our Special Issue, "Biological Foundations of Psychiatric Disorders". We welcome original research, data/bioinformatics papers, hypotheses and opinions, reviews, protocols, and brief communications that deepen our understanding of psychiatric disorders from a molecular and cellular perspective. Topics of interest include the following:

  • Genetic associations and genome-wide studies;
  • Sex-specific molecular and cellular differences;
  • Therapeutic discovery and innovative interventions;
  • Development and application of animal models;
  • Behavioral studies relevant to psychiatric conditions;
  • Tools and techniques for psychiatric research.

By presenting diverse methodologies and research perspectives, this issue aims to advance our knowledge of psychiatric disorders and promote personalized interventions. We encourage submissions that leverage both traditional and cutting-edge approaches to explore these critical topics.

Please feel free to reach out with any questions about the scope or submission process. We look forward to your contributions and appreciate your sharing this call with colleagues.

Warm regards, 

Dr. Rammohan Shukla
Guest Editor

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Keywords

  • psychiatric disorders
  • molecular mechanisms
  • animal models
  • therapeutic discovery
  • genetic associations
  • sex differences
  • protocols
  • methods
  • behavioral studies
  • stress-related phenotypes

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Published Papers (1 paper)

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Review

14 pages, 272 KB  
Review
Cytoskeletal Dynamics and Molecular Motor Dysfunction in Psychiatric Disorders: Insights from Schizophrenia and Autism Spectrum Disorder
by Kenyu Nakamura, Asumi Kubo, Sae Sanaka, Sara Kamiya, Kentaro Itagaki and Tetsuya Sasaki
Biology 2026, 15(7), 550; https://doi.org/10.3390/biology15070550 - 30 Mar 2026
Viewed by 646
Abstract
Elucidating the pathophysiological mechanisms of mental disorders remains a critical challenge in psychiatric research. Recent studies have highlighted the potential involvement of cytoskeletal and molecular motor abnormalities in the development of mental disorders such as schizophrenia and autism spectrum disorder (ASD). Although schizophrenia [...] Read more.
Elucidating the pathophysiological mechanisms of mental disorders remains a critical challenge in psychiatric research. Recent studies have highlighted the potential involvement of cytoskeletal and molecular motor abnormalities in the development of mental disorders such as schizophrenia and autism spectrum disorder (ASD). Although schizophrenia and ASD differ clinically, both disorders are increasingly regarded as neurodevelopmental conditions and share vulnerabilities in synapse formation and neural circuit maturation. This review synthesizes the latest findings on the relationship between cytoskeletal and molecular motor abnormalities and mental disorders. The cytoskeleton, composed of microtubules, actin filaments, and intermediate filaments, along with molecular motors such as kinesins, dyneins, and myosins, plays crucial roles in neurodevelopment, synapse formation, and neurotransmission. In schizophrenia, decreased expression of the microtubule-associated protein MAP2 and abnormalities in the DISC1 gene have been reported, potentially leading to dendritic morphological abnormalities and neurodevelopmental disorders. Additionally, abnormalities in molecular motors such as KIF17 and KIF1A have been implicated in schizophrenia pathophysiology. Myosin Id has been identified as a risk gene for ASD. Furthermore, abnormalities in actin-related proteins such as SHANK3 and CYFIP1 have been shown to cause synaptic dysfunction. These findings suggest that mental disorders arise from complex pathologies involving multiple cytoskeletal and molecular motor-related protein abnormalities. Future research should focus on elucidating the functions of individual proteins and adopting a comprehensive approach that includes glial cells. Advances in this field may deepen our understanding of the pathophysiological mechanisms of mental disorders and potentially lead to the development of novel therapeutic strategies. Full article
(This article belongs to the Special Issue Biological Foundations of Psychiatric Disorders)
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