Complex Signaling Networks in Lung Development and Lung Injury
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 380
Special Issue Editors
Interests: cell biology; regenerative medicine; biomedical engineering; pulmonary biology; tissue engineering; pulmonary fibrosis; pulmonary hypertension
Interests: cell culture; cell biology; protein biochemistry; protein misfolding and aggregation; protein-protein and drug protein interaction; regenerative medicine
Special Issue Information
Dear Colleagues,
Each year, about four million people die prematurely from respiratory diseases. Apart from risk factors such as smoking and air pollution, the predisposition to develop respiratory illness is attributed to internal genetic factors. Several signaling domains constitute this internal factor and dictate the repair and regeneration of the lungs. However, these signaling events and the order in which they operate are still poorly understood.
In this Special Issue, we propose to discuss the role of these complex pulmonary signaling mechanisms in the process of lung development, disease, and regeneration. While the role of pulmonary epithelium in many pathologies is well-studied, the changes in pulmonary vasculature and the contribution of DNA damage, inflammation, and oxidative stress are also being investigated. The advent of tools such as large-scale genomic, epigenomic, and proteomic analysis in human cells along with gene editing using CRISPR/Cas9 and viral vector technologies offer great hope in understanding the pathophysiology of the disease and directing therapies to specific signaling domains.
This Special Issue aims to present manuscripts from basic, applied, clinical, and translational researchers in pulmonary biology to provide their expert views to the scientific community on several biological signaling mechanisms in the lungs. Original research articles, reviews, and short communications are welcome.
Dr. Aja Aravamudhan
Dr. Pinaki P Misra
Dr. Qi Tan
Guest Editors
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Keywords
- respiratory disease
- development
- regeneration
- growth factors
- genomics
- proteomics
- epigenetics
- inflammation
- pollution
- stem cells
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