Tissue Engineering and Regenerative Medicine

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (14 May 2021) | Viewed by 4425

Special Issue Editors


E-Mail Website
Guest Editor
1. Aachen‐Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, 6211 Geleen, The Netherlands
2. Department of Biohybrid & Medical Textiles, RWTH Aachen University, 52062 Aachen, Germany
Interests: tissue engineering; medical textiles; mechanobiology; cell-material interaction; biomaterials

E-Mail Website
Guest Editor
1. Aachen‐Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, Geleen, The Netherlands
2. Department of Biohybrid & Medical Textiles, RWTH Aachen University, Aachen, Germany
Interests: tissue engineering; medical textiles; biomaterials; biohybrid implants

Special Issue Information

The development of functional biological substitutes that restore, maintain, or improve the function of damaged and degenerated tissues or organs has shown to be a more promising treatment option compared to the current gold standards, such as transplantation. Although enormous progress has been made in the field of tissue engineering and regenerative medicine, there is still a significant amount of work to be performed to translate the research into clinical practice.

In order to reach proper regeneration of functional tissues and organs, additional resources need to be focused on topics such as 1) designing appropriate biomaterials capable of controlling the required structure and function of the engineered constructs, 2) understanding the mechanisms of interactions between biomaterials and living systems, 3) in vitro and in vivo tissue remodeling and maturation, and 4) the role of different cues, such as biophysical and biochemical, on the tissue remodeling process.

The aim of this Special Issue is to provide the readers recent examples of research and progress in the fast growing field of tissue engineering and regenerative medicine. Topics include in vitro, in vivo and in situ tissue regeneration and repair, biomaterials, cell-material interaction and biomedical textiles. We believe that future progress in the field of tissue engineering and regenerative medicine that promotes more applications into the clinic will significantly improve the life of millions of people worldwide.

Dr. Samaneh Ghazanfari
Prof. Dr. Stefan Jockenhoevel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue engineering 
  • Regenerative medicine 
  • Cell-material interaction 
  • Biomedical textiles 
  • Biomaterials 
  • Biomechanics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 5823 KiB  
Article
Biocompatibility and Antibiofilm Properties of Calcium Silicate-Based Cements: An In Vitro Evaluation and Report of Two Clinical Cases
by Maurizio Bossù, Patrizia Mancini, Erika Bruni, Daniela Uccelletti, Adele Preziosi, Marco Rulli, Michela Relucenti, Orlando Donfrancesco, Flavia Iaculli, Gianni Di Giorgio, Roberto Matassa, Alessandro Salucci and Antonella Polimeni
Biology 2021, 10(6), 470; https://doi.org/10.3390/biology10060470 - 26 May 2021
Cited by 16 | Viewed by 3541
Abstract
Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties of these bioactive materials, the present study aimed to compare the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine. Human osteogenic [...] Read more.
Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties of these bioactive materials, the present study aimed to compare the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine. Human osteogenic sarcoma (Saos-2) cells were cultured on ProRoot MTA and Biodentine samples or in the presence of both cement extracts. Cell viability assay, measurement of reactive oxygen species (ROS), immunofluorescence analysis, as well as morphological evaluations were conducted. Moreover, Streptococcus mutans was used to assess the biofilm forming ability on ProRoot MTA and Biodentine disks. Finally, both cements were applied in vivo to treat immature permanent teeth affected by reversible pulpitis. Results: Cell viability assay demonstrated that Saos-2 cells had a dose- and time-dependent cytotoxicity to both analyzed cements, although cells exposed to ProRoot MTA showed a better cell vitality than those exposed to Biodentine (p < 0.001). Both cements demonstrated ROS production while this was greater in the case of Biodentine than ProRoot MTA (p < 0.001). Immunofluorescence images of the cytoskeleton and focal adhesions showed no differences in Saos-2 cells grown in the presence of ProRoot MTA eluate; whereas in the Biodentine groups, cells showed a morphology and focal adhesions more similar to that of the control sample, as the eluate concentration decreased. Morphological analysis revealed that Saos-2 cells were more flattened and exhibited better spreading when attached to ProRoot MTA disks than to Biodentine ones. The antibiofilm properties showed a time-dependent powerful inhibition of S. mutans superficial colonization and an antibiofilm effect of both cements. Clinically, complete root formation of the treated elements was achieved using the two studied cements, showing stable results over time. ProRoot MTA and Biodentine was demonstrated to be biocompatible and to possess antibiofilm properties. Their clinical application in vital pulp therapy provided successful outcomes after 2 years of follow-up. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine)
Show Figures

Figure 1

Back to TopTop