Systematic Genome Editing of the Genes on Zebrafish Chromosome by CRISPR/Cas9
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 11439
Special Issue Editors
Interests: genomic features; developmental biology; zebrafish; early embryo; genome editing; CRISPR/Cas9; Wnt signaling; gastrulation; myogenesis; morphogenesis
Special Issues, Collections and Topics in MDPI journals
Interests: zebrafish; genome editing; CRISPR/Cas system; organogenesis; heart regeneration; functional genomics; single-cell transcriptomics; disease modeling
Special Issue Information
Dear Colleagues,
The CRISPR/Cas9 system is a powerful tool in genome editing, with a wide range of potential applications. It has been used successfully in a variety of species, from invertebrates to mammals, making gene editing faster and more accessible than ever. This technology has produced an enormous effect on genetic research. Zebrafish has become particularly attractive for understanding regulatory gene functions and for modeling human diseases. The number of mutant and transgenic lines created by CRISPR/Cas9 is rapidly increasing in this commonly used animal model, which should help to illustrate the genotype–phenotype relationship in the future. It is expected that further improvements of CRISPR/Cas9-mediated conditional knockouts and transgenesis should strongly impact the systematic screening of gene functions and imaging-based cell lineage tracing during embryonic and post-embryonic development.
This Special Issue welcomes submissions of original research and review manuscripts focusing on the application of CRISPR/Cas9 technology and related molecular tools to genome editing in zebrafish, including but not limited to gene targeting and technical development or improvement. The aim is to provide an overview of the exciting advance and the strong potential for systematic analysis of gene functions in development and disease.
Dr. De-Li ShiDr. Bo Zhang
Guest Editors
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Keywords
- Genetics
- Knock-in
- Zebrafish
- Knock-out
- Phenomics
- Transgenesis
- Chromosome
- Disease model
- Gene function
- Regeneration
- CRISPR/Cas9
- Genome editing
- Developmental biology
- Lineage tracing
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