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Acute and Chronic Urticaria: New Insights into Pathogenesis, Diagnosis and...
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Acute and Chronic Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (15 December 2024) | Viewed by 14263

Special Issue Editor

Dr. Angela Rizzi

E-Mail Website
Guest Editor
UOSD Allergologia e Immunologia Clinica, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Interests: food allergy; metal allergy; drug allergy; nasal cytology; immunotherapy; asthma; rhinitis; nasal polyposis, latex allergy; vasculitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Urticaria is a predominantly mast cell–driven disease clinically characterized by wheals and/or angioedema. Urticaria is usually classified based on its duration as acute urticaria, lasting ≤ 6 weeks, or chronic urticaria, lasting > 6 weeks, including chronic spontaneous urticaria and chronic inducible urticaria. Its prevalence has been estimated at 1-2% affecting all age groups.

The etiopathogenesis of this disease is complex and unclear. Since chronic spontaneous urticaria is idiopathic, the search for causes, the optimization of treatment and the multidisciplinary approach to the disease are the pillars of research on this pathology. In addition, in recent years, significant advances in understanding the pathophysiological mechanisms of urticaria have prompted researchers to explore new drugs, particularly biologics, for patients with severe refractory urticaria.

In this Special Issue, we welcome papers (review and original article) that will cover all aspects of urticaria, which include:

  • urticaria in special settings: childhood, pregnancies, immunodeficiencies;
  • emerging pathophysiological aspects;
  • diagnostic work-up;
  • biomarkers of disease activity/severity and of the response to treatment;
  • current and future therapeutic targets

Dr. Angela Rizzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute urticaria
  • chronic urticaria
  • pathogenesis
  • mast cells
  • biomarkers
  • diagnosis
  • biologicals
  • management

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Published Papers (3 papers)

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Research

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11 pages, 1114 KiB  
Article
Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study
by Matea Kuna, Mario Štefanović, Blaženka Ladika Davidović, Nikolina Mandušić, Ines Birkić Belanović and Liborija Lugović-Mihić
Biomedicines 2023, 11(8), 2232; https://doi.org/10.3390/biomedicines11082232 - 9 Aug 2023
Cited by 4 | Viewed by 1573
Abstract
(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: [...] Read more.
(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; p = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; p = 0.036) and DLQI (r = 0.504; p = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients. Full article
(This article belongs to the Special Issue Acute and Chronic Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy)
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Review

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17 pages, 986 KiB  
Review
Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives
by Angela Rizzi, Federica Li Pomi, Riccardo Inchingolo, Marinella Viola, Francesco Borgia and Sebastiano Gangemi
Biomedicines 2024, 12(12), 2765; https://doi.org/10.3390/biomedicines12122765 - 4 Dec 2024
Viewed by 491
Abstract
Background: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment. Recent scientific evidence has unveiled the potential role of a family of molecules known as [...] Read more.
Background: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment. Recent scientific evidence has unveiled the potential role of a family of molecules known as “alarmins” in the pathogenesis of CSU. Methods: Papers focusing on the potential pathogenetic role of alarmins in CSU with diagnostic (as biomarkers) and therapeutic implications, in English and published in PubMed, Scopus, Web of Science, as well as clinical studies registered in ClinicalTrials.gov and the EudraCT Public website, were reviewed. Results: The epithelial-derived alarmins thymic stromal lymphopoietin and IL-33 could be suitable diagnostic and prognostic biomarkers and possible therapeutic targets in CSU. The evidence on the role of non-epithelial-derived alarmins (heat shock proteins, S-100 proteins, eosinophil-derived neurotoxin, β-defensins, and acid uric to high-density lipoproteins ratio) is more heterogeneous and complex. Conclusions: More homogeneous studies on large cohorts, preferably supported by data from international registries, will be able to elucidate the intriguing and complex pathogenetic world of CSU. Full article
(This article belongs to the Special Issue Acute and Chronic Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy)
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23 pages, 2328 KiB  
Review
Urticaria: A Narrative Overview of Differential Diagnosis
by Natale Schettini, Monica Corazza, Cecilia Schenetti, Lucrezia Pacetti and Alessandro Borghi
Biomedicines 2023, 11(4), 1096; https://doi.org/10.3390/biomedicines11041096 - 4 Apr 2023
Cited by 8 | Viewed by 11313
Abstract
Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and [...] Read more.
Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions. Full article
(This article belongs to the Special Issue Acute and Chronic Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy)
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