Recent Advances in Liver Cirrhosis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2764

Special Issue Editor


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Guest Editor
Department of Internal Medicine, Medical University, Lublin, Poland
Interests: liver cirrhosis; liver fibrosis; portal hypertension; acute on chronic liver failure; hepatocellular carcinoma

Special Issue Information

Dear Colleagues,

Liver cirrhosis is a progressive and dynamic chronic liver disease. It is widely prevalent worldwide and can be caused by different causes, such as chronic viral hepatitis, alcohol-associated liver disease, metabolic-associated fatty liver disease/nonalcoholic fatty liver disease (MAFLD/NAFLD) and so on. The major complications of cirrhosis include varices, ascites, hepatic encephalopathy (HE), hepatopulmonary hypertension, hepatocellular carcinoma, hepatorenal syndrome, spontaneous bacterial peritonitis, and coagulation disorders.

The pathogenesis of cirrhosis and its complications is very complex; this is because early diagnosis is often difficult, and the disease usually goes unnoticed for a long time. The pharmacological community has paid very limited attention to the early stages of cirrhosis, resulting in few current drugs targeting liver cirrhosis. Moreover, comorbidities of cirrhosis were ruled out for most of the new drugs.

Therefore, we are excited to inform you of our Special Edition titled “Recent Advances in Liver Cirrhosis” for the journal Biomedicines. We welcome submissions with a focus on the disease burden, pathophysiology, early diagnosis, and monitoring of cirrhosis, and the novelty therapeutic strategies of its complications.

Dr. Andrzej Prystupa
Guest Editor

Manuscript Submission Information

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Keywords

  • liver cirrhosis
  • liver fibrosis
  • portal hypertension
  • cholestatic liver disease
  • liver failure
  • hepatocellular carcinoma
  • non-alcoholic steatohepatitis
  • variceal bleeding

Published Papers (1 paper)

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Review

13 pages, 669 KiB  
Review
B-Blockers in Liver Cirrhosis: A Wonder Drug for Every Stage of Portal Hypertension? A Narrative Review
by Dimitrios S. Karagiannakis, Nikolaos D. Karakousis and Theodoros Androutsakos
Biomedicines 2024, 12(1), 57; https://doi.org/10.3390/biomedicines12010057 - 25 Dec 2023
Cited by 2 | Viewed by 2502
Abstract
In cirrhotic patients, non-selective b-blockers (NSBBs) constitute the reference treatment of choice as monotherapy or combined with band ligation for the prevention of first variceal bleeding and rebleeding, respectively. Furthermore, the last Baveno VII guidelines recommended carvedilol, a b-blocker with additional anti-a1 receptor [...] Read more.
In cirrhotic patients, non-selective b-blockers (NSBBs) constitute the reference treatment of choice as monotherapy or combined with band ligation for the prevention of first variceal bleeding and rebleeding, respectively. Furthermore, the last Baveno VII guidelines recommended carvedilol, a b-blocker with additional anti-a1 receptor activity, in all compensated cirrhotics with clinically significant portal hypertension, to prevent liver decompensation. Interestingly enough, NSBBs have been reported to have a potentially positive impact on the short-term mortality of patients with acute-on-chronic liver failure. However, concerns remain about the use of b-blockers in the presence of severe complications, such as refractory ascites, hepatorenal syndrome, spontaneous bacterial peritonitis, or established cirrhotic cardiomyopathy. In addition, it has not been verified yet whether carvedilol supersedes all the other NSBBs in every stage of liver disease, even when severe complications have developed. Therefore, this review aims to illustrate recent data regarding the potential role of b-blockers across all stages of liver disease, beyond the primary and secondary prophylaxis of variceal bleeding, and address the authors’ proposals on the use of NSBBs concerning the severity of liver disease and the patient’s performance status. Full article
(This article belongs to the Special Issue Recent Advances in Liver Cirrhosis)
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