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Biomedicines
Special Issues
Hair Loss: From Pathophysiology to Therapeutic Perspectives
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Hair Loss: From Pathophysiology to Therapeutic Perspectives

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 5279

Special Issue Editors

Dr. Fabio Rinaldi

E-Mail Website
Guest Editor
Human Microbiome Advanced Project, HMAP, 20129 Milan, Italy
Interests: hair; microbiota; alopecia; dermatology
Dr. Daniela Pinto

E-Mail Website
Guest Editor
Human Microbiome Advanced Project-HMPA, Giuliani SpA, 20129 Milan, Italy
Interests: hair; microbiota; alopecia; dermatology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The purpose of the present Special Issue, "Hair Loss: From Pathophysiology to Therapeutic Perspectives", will be the deepening of current therapeutic practices in the field of trichology, with particular attention to the latest innovations, aiming at providing a comprehensive vision of the field with updates on new developments in terms of pathogenesis, clinical, and diagnostics. Particular attention will be paid to the involvement of the microbiota on the health of the scalp and its implications in the manifestation and exacerbation of scalp pathologies.

Dr. Fabio Rinaldi
Dr. Daniela Pinto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hair
  • immuneprivilege
  • alopecia
  • alopecia areata
  • lichen planopilaris
  • microbiota
  • probiotics
  • PRP

Published Papers (2 papers)

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Review

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14 pages, 310 KiB  
Review
The Hormonal Background of Hair Loss in Non-Scarring Alopecias
by Barbara Owecka, Agata Tomaszewska, Krzysztof Dobrzeniecki and Maciej Owecki
Biomedicines 2024, 12(3), 513; https://doi.org/10.3390/biomedicines12030513 - 24 Feb 2024
Viewed by 3437
Abstract
Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation of the hair growth cycle. This review focuses on the hormonal background of hair loss, including pathophysiology, underlying [...] Read more.
Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation of the hair growth cycle. This review focuses on the hormonal background of hair loss, including pathophysiology, underlying endocrine disorders, and possible treatment options for alopecia. In particular, the role of androgens, including dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), and its sulfate (DHEAS), has been studied in the context of androgenetic alopecia. Androgen excess may cause miniaturization of hair follicles (HFs) in the scalp. Moreover, hair loss may occur in the case of estrogen deficiency, appearing naturally during menopause. Also, thyroid hormones and thyroid dysfunctions are linked with the most common types of alopecia, including telogen effluvium (TE), alopecia areata (AA), and androgenetic alopecia. Particular emphasis is placed on the role of the hypothalamic–pituitary–adrenal axis hormones (corticotropin-releasing hormone, adrenocorticotropic hormone (ACTH), cortisol) in stress-induced alopecia. This article also briefly discusses hormonal therapies, including 5-alpha-reductase inhibitors (finasteride, dutasteride), spironolactone, bicalutamide, estrogens, and others. Full article
(This article belongs to the Special Issue Hair Loss: From Pathophysiology to Therapeutic Perspectives)
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Other

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7 pages, 247 KiB  
Opinion
The Menopausal Transition: Is the Hair Follicle “Going through Menopause”?
by Fabio Rinaldi, Anna Trink, Giorgia Mondadori, Giammaria Giuliani and Daniela Pinto
Biomedicines 2023, 11(11), 3041; https://doi.org/10.3390/biomedicines11113041 - 14 Nov 2023
Cited by 1 | Viewed by 1408
Abstract
This article explores the link between menopause and changes in the hair follicle (HF) lifecycle, focusing on hormonal and metabolic dynamics. During menopause, hormonal fluctuations and aging can impact the HF, leading to phenomena such as thinning, loss of volume, and changes in [...] Read more.
This article explores the link between menopause and changes in the hair follicle (HF) lifecycle, focusing on hormonal and metabolic dynamics. During menopause, hormonal fluctuations and aging can impact the HF, leading to phenomena such as thinning, loss of volume, and changes in hair texture. These changes are primarily attributed to a decrease in estrogen levels. However, not all women experience significant hair changes during menopause, and the extent of transformations can vary considerably from person to person, influenced by genetic factors, stress, diet, and other elements. Furthermore, menopause mirrors the aging process, affecting metabolism and blood flow to the HFs, influencing the availability of vital nutrients. The article also discusses the key role of energy metabolism in the HF lifecycle and the effect of hormones, particularly estrogens, on metabolic efficiency. The concept of a possible “menopause” clinically independent of menopause is introduced, related to changes in HF metabolism, emphasizing the importance of individual factors such as estrogen receptor responses, genetics, and last but not least, the microbiota in determining these dynamics. Full article
(This article belongs to the Special Issue Hair Loss: From Pathophysiology to Therapeutic Perspectives)
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