Drug Targets and Associated Therapeutic Treatments for Parkinson's Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1456
Special Issue Editor
Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD) is multifactorial age-related brain disease characterized by bradykinesia, fatigue, irregular blood pressure and major muscle-stiffness-associated difficulties. Despite extensive research, there is no cure for PD. To make scientific advances regarding therapeutic discoveries and mechanistic approaches to determining the basis of PD progression, PD modeling is a critical step. Currently, available cellular and genetic rodent models remain inefficient. For example, iPSC-based disease modeling and iPSC (induced pluripotent stem cell)-derived neurons (iNs) are not mature enough to recapitulate age-related pathological events, which instead require tools that can accelerate iNs maturation. In a different study, a disease-causing agent extracted from the human brain, supplemented with an in vitro growth media to induce PD pathogenesis, was proven to be a powerful approach to studying pathogen-specific disease induction, which is rapid and pathogen-species-specific; however, it does not eventually mimic the progressive manner of disease. Inducible and genetic rodent models also have pathological characteristics. We strive to improve model systems to allow us to identify cellular mechanisms underpin the development, onset, progression, and end stages of the disease, which are critical for finding successful treatments.
Dr. Brijesh Kumar Singh
Guest Editor
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Keywords
- induced pluripotent stem cell
- neuronal maturation
- Parkinson’s disease
- gene therapy
- PD models
