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Biomedicines
Special Issues
Advanced Research on Heart Failure and Heart Transplantation
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Advanced Research on Heart Failure and Heart Transplantation

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1123

Special Issue Editor

Dr. Nandan Kumar Mondal

E-Mail Website
Guest Editor
Michael E. DeBakey Department of Surgery, Division of Cardiothoracic Transplantation and Circulatory Support, Baylor College of Medicine, Houston, TX 77030, USA
Interests: cardiothoracic transplantation; organ care system; heart failure and mechanical circulatory support; non-physiological high shear stress; extracorporeal membrane oxygenation; robotic-assisted minimally invasive cardiac surgery; cardiopulmonary bypass

Special Issue Information

Dear Colleagues,

This Special Issue explores the critical advancements and ongoing challenges in heart failure, particularly focusing on heart transplantation and organ donation. As the prevalence of heart failure rises globally, innovative strategies in donor selection and preservation techniques become increasingly vital. We invite contributions that delve into various aspects of heart transplantation, including the implications of donation after brain death (DBD) and donation after cardiac death (DCD), as well as the impact of ischemic time on donor heart viability. Furthermore, we encourage authors to discuss the complexities of reperfusion injury and myocardial damage, highlighting emerging research and clinical practices to minimize graft failure. We welcome studies investigating the molecular mechanisms underlying transplant rejection, cellular interactions within the transplanted organ, and innovations in molecular therapy and regenerative medicine on heart transplant outcomes. The role of post-transplant care in improving patient outcomes will also be a central theme, fostering a comprehensive understanding of the transplantation process. Ultimately, this Special Issue seeks to provide a platform for researchers, clinicians, and healthcare professionals to share innovative ideas, recent findings, and collaborative approaches that can enhance the effectiveness of heart transplantation and address the pressing needs in managing heart failure.

Dr. Nandan Kumar Mondal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • heart transplantation
  • DBD (donation after brain death)
  • DCD (donation after cardiac death)
  • cardiac arrest
  • ischemic time and reperfusion injury
  • myocardial damage
  • preservation techniques
  • post-transplant outcomes

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Published Papers (2 papers)

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Research

12 pages, 862 KiB  
Article
Prediction of Kidney Function Improvement After Heart Transplantation
by Jakub Ptak, Mateusz Sokolski, Mateusz Wilk, Mateusz Waloszczyk, Kacper Wiśniewski, Dominik Krupka, Paulina Makowska, Magdalena Cielecka, Maciej Szwajkowski, Mateusz Rakowski, Maciej Bochenek, Roman Przybylski and Michał Zakliczyński
Biomedicines 2025, 13(4), 933; https://doi.org/10.3390/biomedicines13040933 - 10 Apr 2025
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Abstract
Background/Objectives: Patients with advanced heart failure (HF) often suffer from impaired kidney function. Based on the pathophysiology of types I and II of cardiorenal syndrome, heart transplantation (Htx) may restore renal function. The aim of this study was to identify predictors of [...] Read more.
Background/Objectives: Patients with advanced heart failure (HF) often suffer from impaired kidney function. Based on the pathophysiology of types I and II of cardiorenal syndrome, heart transplantation (Htx) may restore renal function. The aim of this study was to identify predictors of improvement in kidney function after HTx. Methods: Htx patients from a tertiary hospital were retrospectively divided into three groups—improvement (n = 24), deterioration (n = 31) and no significant change in eGFR (n = 45)—based on changes in their mean estimated glomerular filtration rate (eGFR) within the first three postoperative months, compared to the last three preoperative months. The threshold for eGFR improvement was defined as a ≥20% increase, while deterioration was defined as a ≥20% decrease. The no significant change group was defined as any change falling between these two values. Results: The median age of analyzed cohort was 54 (45–63) years, and 82% were male. Preoperatively, the improvement group was more frequently treated with inotropes or vasopressors and had significantly higher blood urea and total bilirubin levels before Htx. In the multivariate analysis, total bilirubin before Htx (OR 1.66; 95% CI; 1.24–2.69; p = 0.002) and no need for RRT early after Htx (OR 0.46; 95% CI 0.24–0.88; p = 0.02) were independent predictors of improved kidney function in the first three months after HTx. Conclusions: The improvement in renal function after HTx is uncommon. It could be expected in patients suffering from more severe forms of HF, with impaired kidney and liver function but who did not need RRT after the surgery. Full article
(This article belongs to the Special Issue Advanced Research on Heart Failure and Heart Transplantation)
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12 pages, 4367 KiB  
Article
Exploring the Potential of Voxel-Mirrored Homotopic Connectivity (VMHC) and Regional Homogeneity (ReHo) in Understanding Cognitive Changes After Heart Transplantation
by Qian Qin, Jia Liu, Wenliang Fan, Xinli Zhang, Jue Lu, Xiaotong Guo, Ziqiao Lei and Jing Wang
Biomedicines 2025, 13(4), 873; https://doi.org/10.3390/biomedicines13040873 - 3 Apr 2025
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Abstract
Objective: This study aimed to investigate the application value of voxel-mirrored homotopic connectivity (VMHC) and regional homogeneity (ReHo) in evaluating cognitive impairment after heart transplantation. Methods: A total of 68 heart transplant patients and 56 healthy controls were included. ReHo and [...] Read more.
Objective: This study aimed to investigate the application value of voxel-mirrored homotopic connectivity (VMHC) and regional homogeneity (ReHo) in evaluating cognitive impairment after heart transplantation. Methods: A total of 68 heart transplant patients and 56 healthy controls were included. ReHo and VMHC were calculated using DPARSF software. A two-sample t-test was applied to compare the differences in ReHo and VMHC between the two groups, and a Pearson correlation analysis was performed by extracting the VMHC and ReHo values of different brain regions and correlating them with cognitive scale scores of the patient groups. Results: Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were lower in the heart transplant group than in the control group (MMSE: t = 4.028, p < 0.001; MoCA: t = 4.914, p < 0.001). Compared with the control group, the ReHo values of Frontal_Sup_R (t = −4.422, p < 0.001), Thalamus_L (t = −3.911, p < 0.001), and Calcarine_L (t = −3.640, p < 0.001) were lower in the heart transplantation group, while the ReHo of Temporal_Sup_L was higher (t = 4.609, p < 0.001). VMHC was elevated for bilateral Cerebellum_Crus1 (t = 3.803, p < 0.001) and decreased for bilateral calcarine (t = −3.424, p < 0.001). The ReHo of Frontal_Sup_R was positively correlated with MMSE (r = 0.345, p = 0.004) and MoCA (r = 0.376, p = 0.002). The ReHo of Temporal_Sup_L was also positively correlated with MMSE (r = 0.397, p < 0.001) and MoCA (r = 0.542, p < 0.001). The VMHC of bilateral calcarine showed a positive correlation with MMSE (r = 0.513, p < 0.001) and MoCA (r = 0.398, p < 0.001). Other differential brain regions showed no significant correlation with the MMSE and MoCA scale scores. Conclusions: Cognitive decline was observed in heart transplant patients. Heart transplant patients exhibited altered ReHo and VMHC in several brain regions compared with healthy controls. These changes may underlie impaired cognitive function in heart transplant patients. These findings may contribute to understanding the neural mechanisms of cognitive changes in heart transplant patients and could inform future research on potential intervention strategies. Full article
(This article belongs to the Special Issue Advanced Research on Heart Failure and Heart Transplantation)
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