Molecular Research of Cardiocluster
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 1180
Special Issue Editor
Special Issue Information
Dear Colleagues,
Three dimensional cardiac cell- and tissue-engineering models have been proven to be more effective and more relevant for cardiac cell therapy and disease modeling than conventional 2D culturing, thanks to their exquisite multicellular nature and inter-cellular communication that closely resembles in vivo cardiac microenvironment. CarioCluster, cardiac spheres, microtissue, though these 3D organoids come in diverse terms, one common feature they all share is that these 3D cellular structures are engineered with multiple types of progenitor, stromal, or stem cells, such as cardiomyocytes, iPSCs, endothelial progenitors, epicardial cells, or mesenchymal stem cells. Functionally, cardiac organoids are designed to recapitulate the cell diversity of myocardium, protect cell delivery, and promote angiogenesis and cell survival. Additionally, they harbor the advantage as an in vitro surrogate of heart disease model suitable for drug testing and physiological assessment of cardiac tissue. Identifying and understanding 3D cardiac organoids can accelerate the design and development of cell therapy and future therapeutic tools in treating cardiovascular disease.
This Special issue aims to cover the latest developments of 3D cardiac organoids and their therapeutic potentials. Specifically, identification of novel mechanisms on paracrine signaling and inter-cellular communication within the organoids, advantages as cell therapy product, and application as drug testing model.
Dr. Bingyan J. Wang
Guest Editor
Manuscript Submission Information
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Keywords
- paracrine signaling
- angiogenesis
- cardiac repair
- cardiac drug testing
- cardiac disease model
- scaffolding
- 3D cell engineering
- ECM
- cardiomyocyte
- contractility
