New Advances in Ovarian Cancer

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 695

Special Issue Editor


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Guest Editor
Division of Oncology, Department of Clinical Science Lund, Lund University, S-22381 Lund, Sweden
Interests: cancer research; ovarian cancer; cell signaling; therapeutic target; decidualization

Special Issue Information

Dear Colleagues,

Ovarian cancer remains one of the most challenging malignancies in gynecologic oncology, with ongoing efforts to improve early detection, treatment strategies, and patient outcomes. This Special Issue, titled New Advances in Ovarian Cancer, highlights the latest research and innovations in ovarian cancer, covering key areas such as novel biomarkers, targeted therapies, immunotherapy, precision medicine, and advancements in diagnostic techniques.

This issue will gather contributions from researchers and clinicians, providing a comprehensive overview of current challenges and emerging solutions to foster collaboration and inspire future breakthroughs in ovarian cancer research and treatment by showcasing cutting-edge discoveries and translational approaches.

We cordially invite authors in the field to submit original research or review articles on this important and fast-progressing biomedicine field.

Dr. Zhenshan Yang
Guest Editor

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Keywords

  • ovarian cancer
  • biomarkers
  • cell biology
  • gene regulation
  • target therapy
  • therapeutic resistance
  • precision medicine

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Published Papers (1 paper)

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Research

18 pages, 1665 KB  
Article
Diagnostic Use of Selected Metalloproteinases in Endometrioid Ovarian Cancer
by Ewa Gacuta, Aleksandra Kicman, Paweł Ławicki, Michał Ławicki, Monika Kulesza, Paweł Malinowski, Marcin Chlabicz, Monika Zajkowska and Sławomir Ławicki
Biomedicines 2025, 13(9), 2143; https://doi.org/10.3390/biomedicines13092143 - 2 Sep 2025
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Abstract
Background/Objectives: Endometrioid ovarian cancer (EnOC) is a late-diagnosed gynecological cancer with limited diagnostic methods that, when detected at an early stage, has a good prognosis. This study is the first to evaluate the plasma concentrations and diagnostic utility of selected metalloproteinases as new [...] Read more.
Background/Objectives: Endometrioid ovarian cancer (EnOC) is a late-diagnosed gynecological cancer with limited diagnostic methods that, when detected at an early stage, has a good prognosis. This study is the first to evaluate the plasma concentrations and diagnostic utility of selected metalloproteinases as new biomarkers for EnOC. Methods: The study group consisted of 50 newly diagnosed, untreated patients with EnOC; the control group consisted of 25 patients with endometrial cysts, 25 patients with serous cysts, and 50 healthy women. Selected matrilysins and stromelysins were determined by means of immunoenzymatic assay (ELISA) and routine markers (CA125 and HE4) using the chemiluminescence (CMIA) method. Results: Higher levels of MMP-7, MMP-10, MMP-11, and MMP-26 were found in patients with EnOC when compared to healthy women. Concentrations of MMP-7, MMP-10, and MMP-11 were higher in women with EnOC when compared to benign lesions (BL). The highest SE (98.55%), NPV (95.41%), ACC (57.58%), and AUC (0.9658) values were obtained for MMP-7. High values of diagnostic parameters were also obtained for MMP-11 and MMP-26. Conclusions: These results suggest the usefulness of MMP-7, MMP-26, and MMP-11 in the diagnosis of EnOC as new biomarkers in this pilot study. Full article
(This article belongs to the Special Issue New Advances in Ovarian Cancer)
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