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Biomedicines
Special Issues
Epilepsy: Pathomechanism, Diagnostics, and Novel Treatment Options
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Epilepsy: Pathomechanism, Diagnostics, and Novel Treatment Options

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 376

Special Issue Editors

Dr. Monika Rudkowska

E-Mail Website
Guest Editor
Independent Laboratory of Behavioral Studies, Chair of Biomedical Sciences, Medical University of Lublin, Chodźki 1, 20-400 Lublin, Poland
Interests: Alzheimer's disease; epilepsy; anxiety; depression; addiction; behavioral research; experimental models; schizophrenia; social interactions
Dr. Karolina Wojtunik-Kulesza

E-Mail Website
Guest Editor
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: antioxidants; free radicals; secondary plant metabolites; functional food; neurodegeneration; biological activities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epilepsy is a complex neurological disorder with diverse etiologies and clinical manifestations. Understanding its pathomechanisms is crucial for advancing diagnostics and treatment. This Special Issue aims to highlight recent research on epilepsy, covering molecular mechanisms, novel diagnostic tools, and innovative therapies.

We welcome original research articles, review papers, and case reports focusing on:

  • Molecular and genetic mechanisms of epilepsy;
  • Advances in neuroimaging and electrophysiology;
  • Development of novel biomarkers;
  • Innovative pharmacological and non-pharmacological treatments;
  • Personalized medicine approaches;
  • Methodological advancements in epilepsy research.

By fostering interdisciplinary collaboration, this Special Issue seeks to showcase cutting-edge developments that enhance patient outcomes. We invite contributions from researchers, clinicians, and industry experts.

Dr. Monika Rudkowska
Dr. Karolina Wojtunik-Kulesza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epilepsy
  • pathophysiology
  • neurobiology
  • molecular pathways
  • experimental models of epilepsy
  • neuroinflammation
  • seizure prediction
  • biomarker discovery
  • electrophysiological studies
  • precision neurology

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Published Papers (1 paper)

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Review

31 pages, 412 KB  
Review
Non-Pharmacological Treatment Methods of Lennox–Gastaut Syndrome—Review of the Literature
by Piotr Duda, Michał Granat, Stanisław J. Czuczwar and Barbara Miziak
Biomedicines 2025, 13(9), 2247; https://doi.org/10.3390/biomedicines13092247 - 12 Sep 2025
Viewed by 136
Abstract
Lennox–Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy, often associated with pharmacoresistance. As complete seizure control is usually not achievable with the use of drug therapy, non-pharmacological treatment may be offered to intractable patients. In this review, we are going to [...] Read more.
Lennox–Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy, often associated with pharmacoresistance. As complete seizure control is usually not achievable with the use of drug therapy, non-pharmacological treatment may be offered to intractable patients. In this review, we are going to present literature reports on various non-pharmacological treatments, including surgical and dietary methods. Surgical interventions, such as resective surgery, corpus callosotomy (CC), or neuromodulation therapies such as vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS), can be offered to pharmacoresistant patients. If the epileptogenic area can be detected, resective surgery is a treatment of choice. On the contrary, if non-invasive and invasive diagnostic methods fail to detect epileptogenic lesions, CC and VNS are considered palliative surgical methods. While both CC and VNS are considered effective in seizure reduction, CC is still more popular than VNS, although VNS seems to be related to better tolerability. Although all neuromodulation therapies require multidirectional optimization, DBS appears to be particularly promising for LGS. The classic ketogenic diet (cKD) is considered an effective and well-tolerated method in LGS treatment. The modified Atkins diet (MAD) and the low glycemic index treatment (LGIT) could be used as valuable alternatives due to their lower restrictiveness and better tolerability. Moreover, combinations of several treatment methods could significantly improve LGS patients’ seizure outcomes. Full article
(This article belongs to the Special Issue Epilepsy: Pathomechanism, Diagnostics, and Novel Treatment Options)
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