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Biomedicines
Special Issues
Pathology, Prevention, Diagnosis and Treatments for Gestational Diabetes
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Pathology, Prevention, Diagnosis and Treatments for Gestational Diabetes

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1579

Special Issue Editor

Dr. Yuan-Horng Yan

E-Mail Website
Guest Editor
1. Department of Endocrinology and Metabolism, Kuang Tien General Hospital, Taichung City 433, Taiwan
2. Department of Medicine Research, Kuang-Tien General Hospital, Taichung City 433, Taiwan
3. Department of Nutrition and Institute of Biomedical Nutrition, Hungkuang University, Taichung City 433, Taiwan
Interests: Internal medicine, endocrinology, gestational diabetes mellitus, diabetes mellitus, epidemiology, inhalation toxicology; public health

Special Issue Information

Dear Colleagues,

Gestational diabetes mellitus (GDM) is a type of diabetes mellitus that occurs during pregnancy and can have serious health consequences for both the mother and fetus. The prevalence of GDM is increasing worldwide, and it is estimated to affect around 16% of all pregnancies. This Special Issue of Biomedicines entitled "Advanced Research on Gestational Diabetes" aims to provide a comprehensive overview of the latest advances in the field of GDM research. The scope of this Special Issue covers a wide range of topics, including the epidemiology, pathophysiology and mechanisms, screening, diagnosis, management, and prevention of GDM. This Special Issue also emphasizes the significance of gene–environment interactions in relation to GDM, including factors such as ambient air pollution, toxicology and epigenetic mechanisms. Furthermore, the Special Issue also highlights the importance of interdisciplinary collaboration and the need for personalized management of GDM.

Dr. Yuan-Horng Yan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gestational diabetes mellitus
  • epidemiology
  • pathophysiology
  • screening
  • prevention
  • air pollution
  • toxicology
  • epigenetics
  • interdisciplinary collaboration
  • patient-centered care

Published Papers (1 paper)

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Research

12 pages, 985 KiB  
Article
Risks after Gestational Diabetes Mellitus in Taiwanese Women: A Nationwide Retrospective Cohort Study
by Shih-Ting Tseng, Ming-Chang Lee, Yi-Ting Tsai, Mei-Chun Lu, Su-Chen Yu, I-Ju Tsai, I-Te Lee and Yuan-Horng Yan
Biomedicines 2023, 11(8), 2120; https://doi.org/10.3390/biomedicines11082120 - 27 Jul 2023
Cited by 2 | Viewed by 1393
Abstract
Objective: An increasing trend in the prevalence of gestational diabetes mellitus (GDM) has been reported in Taiwan. GDM has been linked to various adverse maternal outcomes over a long period, including cardiovascular disease (CVD) and chronic kidney disease (CKD). However, evidence implies that [...] Read more.
Objective: An increasing trend in the prevalence of gestational diabetes mellitus (GDM) has been reported in Taiwan. GDM has been linked to various adverse maternal outcomes over a long period, including cardiovascular disease (CVD) and chronic kidney disease (CKD). However, evidence implies that the effects of GDM on the mid-term surrogate risk factors for these diseases are limited. Furthermore, data from nationwide cohort studies are limited. The primary aim of this study was to investigate the risk of developing type 2 diabetes mellitus (T2DM), arterial hypertension (aHTN), and hyperlipidemia (HL) through a 5-year follow-up post-delivery of women with GDM in a nationwide cohort study in Taiwan. The second objective was to investigate the risk of developing insulin resistance syndrome (IRS)-related diseases, including CVD, acute myocardial infarction (AMI), peripheral artery occlusive disease (PAOD), non-alcoholic fatty liver diseases (NAFLD), and CKD. Methods: This was a retrospective, population-based nationwide cohort study. The data source comprises a merge of the Birth Certificate Application Database (BCA) and the National Health Insurance Research Database in Taiwan. Women aged between 15 and 45 years who gave birth in Taiwan between 2004 and 2011 were included. Women who were enrolled and had a GDM diagnosis were assigned to the exposure group. Women who were enrolled without a GDM diagnosis were assigned to the comparison group. The relative risk of developing T2DM, aHTN, HL, and IRS-related diseases, including CVD, AMI, PAOD, NAFLD, and CKD, were analyzed and presented as hazard ratio (HR) through Cox regression and log-rank regression analyses. Results: A total of 1,180,477 women were identified through the BCA database between 2004 and 2011. Of those, 71,611 GDM-diagnosed women and 286,444 women without GDM were included in the final analysis. After adjusting for age, pre-existing cancer, and parity, developing T2DM, aHTN, and HL were still significantly increased in the GDM group (HR and interquartile range (IQR): 2.83 (2.59, 3.08), 1.09 (1.01, 1.06), and 1.29 (1.20, 1.38), accordingly). CVD, NAFLD, and CKD had a very low incidence and showed insignificant results. Conclusion: Our findings provide nationwide cohort data showing that GDM increased the risk of developing T2DM, aHTN, and HL 5 years after delivery within the same group. The GDM complications and risk of CVD, AMI, PAOD, NAFLD, and CKD need further investigation. Full article
(This article belongs to the Special Issue Pathology, Prevention, Diagnosis and Treatments for Gestational Diabetes)
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