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Biomedicines
Special Issues
Relationship between Gastrointestinal Tumors and the Immune Microenvironment
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Relationship between Gastrointestinal Tumors and the Immune Microenvironment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2074

Special Issue Editor

Dr. Ximing Xu

E-Mail Website
Guest Editor
1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China
2. Faculty of Medicine, Wuhan University, Wuhan, China
Interests: gastrointestinal tumors; immunotherapy; diagnosis

Special Issue Information

Dear Colleagues,

The microenvironment of gastrointestinal tumors influences tumor initiation, progression, metastasis, and drug resistance through dynamic interactions with cancer cells. A number of therapies have been developed to target the immune microenvironment of tumors, such as checkpoint blockade and chimeric antigen receptor (CAR) T-cell therapy. Although these treatments offer hope to patients with advanced cancer, their side effects cannot be ignored. Therefore, more research is needed to elucidate the composition and main regulators of the immune microenvironment of gastrointestinal tumors and the interactions between gastrointestinal tumors and their immune microenvironment in order to develop more precise, safe and effective immunotherapeutic approaches to improve patient prognosis.

Dr. Ximing Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal tumors
  • immune microenvironment
  • immunotherapy
  • biomarkers
  • prognosis

Published Papers (1 paper)

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Research

17 pages, 2708 KiB  
Article
Histological Type, Cytotoxic T Cells and Macrophages in the Tumor Microenvironment Affect the PD-L1 Status of Gastric Cancer
by Tomislav Ivanović, Dorotea Božić, Benjamin Benzon, Vesna Čapkun, Katarina Vukojević and Merica Glavina Durdov
Biomedicines 2023, 11(3), 709; https://doi.org/10.3390/biomedicines11030709 - 25 Feb 2023
Cited by 1 | Viewed by 1711
Abstract
Gastric cancer (GC) therapies include gastrectomy and chemoradiotherapy. The tumor immune microenvironment (TME) has implications for potential immunotherapy. We analyzed the expression of PD-L1, CD8, CTLA-4 and IFN-γ in the tumor and regional lymph node (LN) of patients with GC and compared it [...] Read more.
Gastric cancer (GC) therapies include gastrectomy and chemoradiotherapy. The tumor immune microenvironment (TME) has implications for potential immunotherapy. We analyzed the expression of PD-L1, CD8, CTLA-4 and IFN-γ in the tumor and regional lymph node (LN) of patients with GC and compared it with clinical and pathological data. Paraffin blocks were collected from 97 patients undergoing gastrectomy/lymphadenectomy for GC. Double immunohistochemistry was performed for CD8 and PD-L1 and double immunofluorescence for CTLA-4 and IFN-γ. Statistical significance was set at p < 0.05. PD-L1 expression in tumor cells was associated with intestinal GC type (p = 0.046), the density of macrophages and CD8 + T cells (p < 0.001, both). The median number of CD8+ T cells was higher in PD-L1-positive than in -negative tumors. A cut-off of 28.5 CD8 + T cells in one high-magnification field predicted PD-L1-positive tumors (AUROC 0.797, sensitivity 74.2%, specificity 77.3%). IFN-γ expression in tumor cells was found in 37 GCs and was positively associated with CTLA4+ lymphocytes in the LN (p = 0.027) and CTLA4+/IFN-γ+ in tumors and the LN (all p < 0.001). The median overall survival (OS) was 17 months. In the group of deceased patients, IFN-γ expression in metastases correlated with lower OS (RHO = −0.314, p = 0.008). PD-L1 expression in tumor cells correlated with CD8 + T cells and macrophages in the TME and IFN-γ expression with suppressive CTLA4+/IFNγ+ immune cells in the TME and LN. Full article
(This article belongs to the Special Issue Relationship between Gastrointestinal Tumors and the Immune Microenvironment)
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