Sphingolipid Metabolism and Signaling in Health and Diseases: 2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 738
Special Issue Editors
Interests: sphingolipids; neurodegenerative disorders; GM1 ganglioside; lysosomes
Special Issues, Collections and Topics in MDPI journals
Interests: glycosphingolipids; gangliosides; GM1; GM1 oligosaccharide; plasma membrane signaling; neuronal disease; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals
Interests: gangliosides; GM1 ganglioside; neurodegenerative and neurodevelopmental disor-ders; mitochondria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sphingolipids are a class of lipids highly expressed in eukaryotic cells, where they represent key components of membranes. In addition to their structural role, they act as bioactive molecules capable of modulating intracellular signaling and, accordingly, several cell functions, including cell proliferation, differentiation, migration and apoptosis. Consequently, alterations in sphingolipid metabolism and signaling have been associated with several pathological conditions, spanning from neurodegeneration to cancer and diabetes. However, a complete comprehension of the molecular mechanism by which sphingolipids regulate cell homeostasis is still lacking. Providing new information about sphingolipid signaling and metabolism is pivotal for addressing their role both in health and in diseases.
In this Special Issue “Sphingolipid Metabolism and Signaling in Health and Disease”, we aim to collect original research and review articles regarding the role of sphingolipids in modulating cellular functions in different physiopathological conditions.
Dr. Giulia Lunghi
Dr. Elena Chiricozzi
Dr. Maria Fazzari
Guest Editors
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Keywords
- sphingolipids
- glycosphingolipids
- gangliosides
- sphingosine-1-phosphate
- cell homeostasis
- neurodegeneration
- neurodevelopment
- inflammation
- diabetes
- cystic fibrosis
- cancer
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