Diagnosis, Pathogenesis, Treatment and Prognosis of Glioblastoma, 2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 6
Special Issue Editor
Interests: neuro-oncologia; cirurgia de tumores cerebrais com o doente acordado e mapeamento cerebral; cirurgia de tumores cerebrais com imunofluorescência; cirurgia de gliomas de baixo grau; cirurgia da epilepsia; cirurgia intracraniana; patologia da coluna vertebral
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Special Issue Information
Dear Colleagues,
Are genetic changes already adequately known to determine the biological behavior of glioblastomas? Will there be immunotherapy and effective directed treatments for glioblastomas? What is the best treatment for elderly patients and for patients with multicentric lesions? What role does reirradiation play? What has been the experience so far with LITT and TTF?
Despite the fact that advances in molecular characterization and treatments have been made recently, the prognosis remains poor, with most patients dying within 15–18 months. In the USA, the 5-year survival rate has been reported to be 6.8%.
Despite the longer genetic and molecular assessment of glioblastoma, the standard treatment is still a combination of surgery, radiotherapy, and chemotherapy; thus, significant ongoing challenges remain for the treatment of glioblastoma.
The relationship between genetic and molecular changes and image findings may allow for the elucidation of different diagnostic approaches.
Understanding glioblastoma and its pathogenesis is critical for researching new forms of treatment as well as understanding its resistance mechanisms and escape from immune surveillance.
In addition to immunotherapy and target therapies, non-pharmacological options such as TTFs and LITT have emerged as viable treatment options, although the results of these techniques are currently uncertain.
Here, we aim to provide answers to some of these questions, and other questions that will remain unanswered will almost certainly be raised.
Prof. Dr. Paulo Linhares
Guest Editor
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Keywords
- glioblastoma
- immunotherapy
- molecular subtype
- radiotherapy
- molecular therapy
- emerging treatment
- drug resistance
- MRI
- immune surveillance
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