Advanced Research in Reperfusion of Cardiac Injury
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3460
Special Issue Editor
Interests: ischemic and reperfusion heart damage; opioid receptor; conditioning; high altitude hypoxia; NO-syntase; kinases; mitochondria
Special Issue Information
Dear Colleagues,
It is generally accepted that only the restoration of coronary blood flow can affect infarct size. However, reperfusion injury (RI) is responsible for up to 50% of final infarct size. Many factors are involved in cell death during reperfusion, among which the most important are reactive oxygen species production, Ca2+ overload, and inflammation. In recent decades, many pathways of regulated cell death have been investigated. Reperfusion induces cell death as a result of necrosis, necroptosis, apoptosis, pyroptosis, ferroptosis and possibly autophagy. It has also been demonstrated that the NLRP3 inflammasome is involved in RI of the heart. Unfortunately, there are no drugs that could effectively prevent reperfusion injury that occurs after restoration of coronary perfusion in patients with acute myocardial infarction. Studies of the mechanisms of reperfusion injury can be used for search of pharmacological targets for protecting the myocardium against RI.
Therefore, the aim of this Special Issue of Biomedicines entitled “Advanced Research in Reperfusion of Cardiac Injury” is an overview of the current state of research, promoting new understanding of the mechanisms of RI, and considering possible approaches to correct RI.
Both original articles and reviews consistent with this research topic will be considered for publication in this Special Issue. Both original articles and reviews will be considered for publishing in this Special Issue.
Dr. Natalia V. Naryzhnaya
Guest Editor
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Keywords
- reperfusion
- cell death pathways
- cardiac protection
- myocardial conditioning
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