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Biomedicines
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MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0
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MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 7162

Special Issue Editor

Dr. Eric Huet

E-Mail Website
Guest Editor
TRePCa—Therapeutic Resistance in Prostate Cancer, Université Paris-Est Créteil, F-94010 Creteil, France
Interests: matrix biology; tumor microenvironment; matric metalloproteinases; extracellular vesicles; tissue remodeling; cell interactions; EMMPRIN
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

MMPs have been implicated in numerous physiological and pathological situations, such as neoplasia, osteogenesis, myocardial infarction, osteoarthritis, or inflammation. Wide-ranging evidence has also implicated MMP dysregulation in tumor invasion, neoangiogenesis, and metastasis. EMMPRIN, a membrane glycoprotein greatly enriched on the surface of tumor cells, has been shown to stimulate the synthesis of MMPs in stromal cells and may account for the increased MMP expression in most cancer tissues. Apart from direct cell contact, cell interactions can also be influenced by soluble factors such as cytokines, growth factors, or extracellular vesicles. Such nodes of communication between cells might lead to dysregulations of ECM remodeling in physiological and pathological processes. In this Special Issue, original and review articles on basic science and preclinical and clinical findings are warmly welcome to contribute to our understanding of MMPs and their regulations.

Dr. Eric Huet
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • matrix metalloproteinases
  • EMMPRIN
  • tissue remodeling
  • cell interactions
  • physiopathology

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Published Papers (3 papers)

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Research

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15 pages, 2753 KiB  
Article
Correlation of TIMP1-MMP2/MMP9 Gene Expression Axis Changes with Treatment Efficacy and Survival of NSCLC Patients
by Jacek Pietrzak, Agnieszka Wosiak, Dagmara Szmajda-Krygier, Rafał Świechowski, Mariusz Łochowski, Milena Pązik and Ewa Balcerczak
Biomedicines 2023, 11(7), 1777; https://doi.org/10.3390/biomedicines11071777 - 21 Jun 2023
Cited by 4 | Viewed by 2156
Abstract
In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in the microenvironment, including the extracellular matrix (ECM), which is not only a scaffold for cells, but also a reservoir of cytokines, chemokines and growth factors. Metalloproteinases [...] Read more.
In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in the microenvironment, including the extracellular matrix (ECM), which is not only a scaffold for cells, but also a reservoir of cytokines, chemokines and growth factors. Metalloproteinases (MMPs) are among the elements that enable ECM remodeling. The publication focuses on the problem of changes in the gene expression of MMP2, MMP9 and tissue inhibitor of metalloproteinases (TIMP1) in the blood of NSCLC patients during therapy (one year after surgical resection of the tumor). The paper also analyzes differences in the expression of the studied genes in the tumor tissue, as well as data collected in publicly available databases. The results of blood tests showed no differences in the expression of the tested genes during therapy; however, changes were observed in cancerous tissue, which was characterized by higher expression of MMP2 and MMP9, compared to non-cancerous tissue, and unchanged expression of TIMP1. Nevertheless, higher expression of each of the studied genes was associated with shorter patient survival. Interestingly, it was not only the increased expression of metalloproteinase genes, but also the increased expression of the metalloproteinase inhibitor (TIMP1) that was unfavorable for patients. Full article
(This article belongs to the Special Issue MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0)
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Review

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16 pages, 1112 KiB  
Review
Hydrogen Sulfide Modulation of Matrix Metalloproteinases and CD147/EMMPRIN: Mechanistic Pathways and Impact on Atherosclerosis Progression
by Constantin Munteanu, Anca Irina Galaction, Mădălina Poștaru, Mariana Rotariu, Marius Turnea and Corneliu Dan Blendea
Biomedicines 2024, 12(9), 1951; https://doi.org/10.3390/biomedicines12091951 - 26 Aug 2024
Cited by 1 | Viewed by 1826
Abstract
Atherosclerosis is a chronic inflammatory condition marked by endothelial dysfunction, lipid accumulation, inflammatory cell infiltration, and extracellular matrix (ECM) remodeling within arterial walls, leading to plaque formation and potential cardiovascular events. Key players in ECM remodeling and inflammation are matrix metalloproteinases (MMPs) and [...] Read more.
Atherosclerosis is a chronic inflammatory condition marked by endothelial dysfunction, lipid accumulation, inflammatory cell infiltration, and extracellular matrix (ECM) remodeling within arterial walls, leading to plaque formation and potential cardiovascular events. Key players in ECM remodeling and inflammation are matrix metalloproteinases (MMPs) and CD147/EMMPRIN, a cell surface glycoprotein expressed on endothelial cells, vascular smooth muscle cells (VSMCs), and immune cells, that regulates MMP activity. Hydrogen sulfide (H₂S), a gaseous signaling molecule, has emerged as a significant modulator of these processes including oxidative stress mitigation, inflammation reduction, and vascular remodeling. This systematic review investigates the mechanistic pathways through which H₂S influences MMPs and CD147/EMMPRIN and assesses its impact on atherosclerosis progression. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases, focusing on studies examining H₂S modulation of MMPs and CD147/EMMPRIN in atherosclerosis contexts. Findings indicate that H₂S modulates MMP expression and activity through transcriptional regulation and post-translational modifications, including S-sulfhydration. By mitigating oxidative stress, H₂S reduces MMP activation, contributing to plaque stability and vascular remodeling. H₂S also downregulates CD147/EMMPRIN expression via transcriptional pathways, diminishing inflammatory responses and vascular cellular proliferation within plaques. The dual regulatory role of H₂S in inhibiting MMP activity and downregulating CD147 suggests its potential as a therapeutic agent in stabilizing atherosclerotic plaques and mitigating inflammation. Further research is warranted to elucidate the precise molecular mechanisms and to explore H₂S-based therapies for clinical application in atherosclerosis. Full article
(This article belongs to the Special Issue MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0)
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42 pages, 1611 KiB  
Review
Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness
by Raffaele Carrano, Martina Grande, Eleonora Leti Maggio, Carlotta Zucca, Riccardo Bei, Camilla Palumbo, Chiara Focaccetti, Daniela Nardozi, Valeria Lucarini, Valentina Angiolini, Patrizia Mancini, Francesca Barberini, Giovanni Barillari, Loredana Cifaldi, Laura Masuelli, Monica Benvenuto and Roberto Bei
Biomedicines 2024, 12(3), 482; https://doi.org/10.3390/biomedicines12030482 - 21 Feb 2024
Cited by 3 | Viewed by 2292
Abstract
Focal adhesion plaques (FAPs) play an important role in the communication between cells and the extracellular matrix (ECM) and in cells’ migration. FAPs are macromolecular complexes made by different proteins which also interact with matrix metalloproteinases (MMPs). Because of these fundamental properties, FAPs [...] Read more.
Focal adhesion plaques (FAPs) play an important role in the communication between cells and the extracellular matrix (ECM) and in cells’ migration. FAPs are macromolecular complexes made by different proteins which also interact with matrix metalloproteinases (MMPs). Because of these fundamental properties, FAPs and MMPs are also involved in cancer cells’ invasion and in the metastatic cascade. The most important proteins involved in FAP formation and activity are (i) integrins, (ii) a complex of intracellular proteins and (iii) cytoskeleton proteins. The latter, together with MMPs, are involved in the formation of filopodia and invadopodia needed for cell movement and ECM degradation. Due to their key role in cancer cell migration and invasion, MMPs and components of FAPs are often upregulated in cancer and are thus potential targets for cancer therapy. Polyphenols, a large group of organic compounds found in plant-based food and beverages, are reported to have many beneficial healthy effects, including anticancer and anti-inflammatory effects. In this review, we discuss the growing evidence which demonstrates that polyphenols can interact with the different components of FAPs and MMPs, inhibit various pathways like PI3K/Akt, lower focal adhesion kinase (FAK) phosphorylation and decrease cancer cells’ invasiveness, leading to an overall antitumoral effect. Finally, here we highlight that polyphenols could hold potential as adjunctive therapies to conventional cancer treatments due to their ability to target key mechanisms involved in cancer progression. Full article
(This article belongs to the Special Issue MMPs and EMMPRIN/CD147 in Physiological and Pathological Processes 2.0)
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