Advances in Precision Cancer Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 691

Special Issue Editor


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Guest Editor
Xiangya Hospital, Central South University, Changsha, China
Interests: cancer; structural biology; drug development

Special Issue Information

Dear Colleagues,

Cancer precision therapy utilizes a range of techniques, such as genomic analysis and molecular diagnostics, to identify specific genetic and molecular abnormalities in cancer cells and design treatments that selectively target these abnormalities. This approach can lead to more effective and personalized cancer treatment plans, improved patient outcomes, and fewer side effects.

The scope of cancer precision therapy includes targeted therapies, immunotherapies, and other emerging approaches such as CAR-T cell therapy. These therapies can also be used in combination with other cancer treatments, such as chemotherapy and radiotherapy, to improve their effectiveness. The field of cancer precision therapy has been evolving in recent years, with new techniques and methods being developed to improve the accuracy and effectiveness of cancer treatments.

In this Special Issue, we welcome research and review articles focusing on the recent advances in the field of cancer precision therapy.

Prof. Dr. Yongheng Chen
Guest Editor

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Keywords

  • personalized cancer therapy
  • targeted therapy
  • immunotherapy
  • cancer genomics
  • cancer biomarker
  • liquid biopsy
  • CAR-T cell therapy
  • kinase inhibitor
  • combination therapy
  • molecular profiling

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Published Papers (1 paper)

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Review

24 pages, 726 KB  
Review
Transcriptomic Comparisons of Somatic and Cancer Stem Cells
by Austin Drysch, Arun Ahuja, Dillan Prasad, Rishi Jain, Sharbel Romanos, Amr Alwakeal and Christopher Ahuja
Biomedicines 2025, 13(8), 2039; https://doi.org/10.3390/biomedicines13082039 - 21 Aug 2025
Viewed by 468
Abstract
Stem cells are essential for tissue maintenance, repair, and regeneration, yet their dysregulation gives rise to cancer stem cells (CSCs), which drive tumor progression, metastasis, and therapy resistance. Despite extensive research on stemness and oncogenesis, a critical gap remains in our understanding of [...] Read more.
Stem cells are essential for tissue maintenance, repair, and regeneration, yet their dysregulation gives rise to cancer stem cells (CSCs), which drive tumor progression, metastasis, and therapy resistance. Despite extensive research on stemness and oncogenesis, a critical gap remains in our understanding of how the transcriptomic landscapes of normal somatic stem cells (SSCs) diverge from those of CSCs to enable malignancy. This review synthesizes current knowledge of the key signaling pathways (Wnt, Notch, Hedgehog, TGF-β), transcription factors (Oct4, Sox2, Nanog, c-Myc, YAP/TAZ), and epigenetic mechanisms (chromatin remodeling, DNA methylation, microRNA regulation) that govern stemness in SSCs and are hijacked or dysregulated in CSCs. We highlight how context-specific modulation of these pathways distinguishes physiological regeneration from tumorigenesis. Importantly, we discuss the role of epithelial–mesenchymal transition (EMT), cellular plasticity, and microenvironmental cues in reprogramming and maintaining CSC phenotypes. By integrating transcriptomic and epigenetic insights across cancer biology and regenerative medicine, this review provides a framework for identifying vulnerabilities specific to CSCs while still preserving normal stem cell function. Understanding these distinctions is essential for the development of targeted therapies that minimize damage to healthy tissues and advance precision oncology. Full article
(This article belongs to the Special Issue Advances in Precision Cancer Therapy)
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