Molecular Mechanisms in Anaphylaxis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 4627
Special Issue Editor
2. Faculty of Medicine and Biomedicine, Alfonso X El Sabio University, 28691 Madrid, Spain
Interests: anaphylaxis; immunology; vascular permeability; endothelium; molecular mechanisms; extracellular vesicles; miRNAs
Special Issue Information
Dear Colleagues,
Anaphylaxis (AX) is the most severe manifestation of allergic disorders, being a systemic hypersensitivity life-threatening reaction that evolves rapidly. Among the most frequent triggers are food, drugs, and hymenoptera venoms. The plethora of features associated with AX confers difficulties in its diagnosis, impairing the ability to adequately treat these severe reactions. Generally, the diagnosis is carried out according to the clinical symptoms, which are common to many other pathologies, so confirmation through in vitro markers and knowledge about their molecular mechanisms is advisable. Mast cells and basophils are recognized as effector cells eliciting the anaphylactic reaction. However, many other cells and mediators are also relevant. Moreover, the release of mediators causes an endothelial barrier breakdown. This fact produces an increase in vascular permeability and a leakage of fluids, which have influence in two decisive and severe factors (hypotension and hypoxia). Thus, the primary purpose of this Special Issue is to collect scientific contributions providing novel insight into the molecular mechanisms of AX.
Dr. Vanesa Esteban
Guest Editor
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Keywords
- anaphylaxis
- molecular mechanisms
- mast cells
- vascular permeability
- food and drug allergies
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