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Biomedicines
Special Issues
Age-Related Macular Degeneration: Causes, Pathogenesis, Diagnosis, and Intervention
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Age-Related Macular Degeneration: Causes, Pathogenesis, Diagnosis, and Intervention

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2202

Special Issue Editor

Prof. Dr. David Pei-Cheng Lin

E-Mail Website
Guest Editor
Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City 402, Taiwan
Interests: eye drop; dry eye syndromes; tear film; retinopathy, age-related macular degeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Age-related macular degeneration is among the leading causes of blindness in the aged population. Studies performed over the previous decade have unveiled novel insights into the risk factors and pathogenesis of AMD. However, the most prominent advance in AMD treatment is only limited to the use of anti-vascular endothelial growth factor therapies against neovascular AMD. For dry AMD, effective treatments remain elusive in terms of the prevention or elimination of geographical atrophy and drusen formation. The scope of this Special Issue will encompass the causes, pathogenesis and diagnosis of AMD, as well as potential methods of intervention. Potential sub-topics are listed below, with updates on experimental treatment modalities, including cell therapy and therapeutics with cellular derivatives, including extracellular vesicles and secretome, and artificial intelligence-related techniques for AMD management being particularly welcome.

  • Age-related macular degeneration (AMD)
  • Nonexudative or dry AMD
  • Exudative or wet AMD
  • Non-neovascular AMD
  • Neovascular AMD
  • Pathogenesis
  • Risk factors
  • Diagnosis
  • Prevention
  • Treatments, including cell therapy and therapeutics with cellular derivatives
  • Artificial intelligence-related techniques for AMD management

Prof. Dr. David Pei-Cheng Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • age-related macular degeneration (AMD)
  • risk factors
  • prevention
  • pathogenesis
  • intervention

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Published Papers (1 paper)

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Research

20 pages, 1323 KiB  
Article
CFH (rs1061170, rs1410996), KDR (rs2071559, rs1870377) and KDR and CFH Serum Levels in AMD Development and Treatment Efficacy
by Dzastina Cebatoriene, Alvita Vilkeviciute, Greta Gedvilaite, Akvile Bruzaite, Loresa Kriauciuniene, Dalia Zaliuniene and Rasa Liutkeviciene
Biomedicines 2024, 12(5), 948; https://doi.org/10.3390/biomedicines12050948 - 24 Apr 2024
Cited by 2 | Viewed by 1000
Abstract
Background: Age-related macular degeneration (AMD) is a major global health problem as it is the leading cause of irreversible loss of central vision in the aging population. Av-vascular endothelial growth factor (anti-VEGF) therapies have been shown to be effective, but they do not [...] Read more.
Background: Age-related macular degeneration (AMD) is a major global health problem as it is the leading cause of irreversible loss of central vision in the aging population. Av-vascular endothelial growth factor (anti-VEGF) therapies have been shown to be effective, but they do not respond optimally to all patients. Objective. This study investigates the genetic factors associated with susceptibility to AMD and response to treatment, focusing on key polymorphisms in the CFH (rs1061170, rs1410996) and KDR (rs2071559, rs1870377) genes and the association of CFH and KDR serum levels in patients with AMD. Results. A cohort of 255 patients with early AMD, 252 patients with exudative AMD, and 349 healthy controls underwent genotyping analysis, which revealed significant associations between CFH polymorphisms and the risk of exudative AMD. The CFH rs1061170 CC genotype was associated with an increased risk of early AMD (p = 0.046). For exudative AMD, the CFH rs1061170 TC + CC genotype increased odds (p < 0.001), while the rs1410996 GA + AA genotype decreased odds (p < 0.001). Haplotypes of CFH SNPs were associated with decreased odds of AMD. In terms of response to treatment, none of the SNPs were associated with the response to anti-VEGF treatment. We also found that both early and exudative AMD patients had lower CFH serum levels compared to the control group (p = 0.038 and p = 0.006, respectively). Exudative AMD patients with the CT genotype of CFH rs1061170 had lower CFH serum levels compared to the control group (p = 0.035). Exudative AMD patients with the GG genotype of CFH rs1410996 also had lower CFH serum levels compared to the control group (p = 0.021). Conclusions. CFH polymorphisms influence susceptibility to AMD but do not correlate with a response to anti-VEGF therapy. Further research is imperative to fully evaluate the developmental significance, treatment efficacy, and predictive role in influencing susceptibility to anti-VEGF therapy for KDR and CFH. Full article
(This article belongs to the Special Issue Age-Related Macular Degeneration: Causes, Pathogenesis, Diagnosis, and Intervention)
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