Multigene Assays in Early Breast Cancer: Implications for Classification, Staging, Prognosis and Treatment
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 8715
Special Issue Editors
Interests: breast cancer; breast cancer translational research; prognostic and predictive breast cancer biomarkers; breast cancer new drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last two decades, a new conceptual approach to breast cancer (BC) has emerged, providing a better understanding of the biology of the disease. With the advent of genomic analyses, it has become evident that BC is not a single type of tumor, but a group of different diseases with distinct molecular properties, eventually defined by the use of multigene assays (MGAs). Each of these different molecular properties identify different BC subtypes that tend to respond differently to anticancer therapy. This has fueled the promise of MGAs to provide detailed and specific molecular information, which will ultimately lead to individualized and more precise BC treatment, along with a more accurate BC classification and staging.
Actually, MGAs may contribute to optimizing treatment decision-making in early-stage breast cancer (eBC), enabling selective use of adjuvant chemotherapy more effectively than can be achieved with conventional clinicopathologic parameters. Different types of MGAs are now available in the daily clinical practice, including Oncotype DX®, MammaPrint®, Endopredict®, Prosigna®, and the Breast Cancer Index® (BCI). The use of MGAs is supported by evidence from retrospective and prospective studies, but controversies still remain in specific and comparative clinical utility analyses of different MGAs in eBC.
This Special Issue focuses on the role and impact of the different MGAs in eBC and their implications for classification, staging, prognosis, and treatment. We cordially invite authors in the field to submit original research or review articles pertaining to this important and progressing field of biomedicine.
Dr. Alberto Zambelli
Dr. Carlo Tondini
Guest Editors
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Keywords
- early-stage breast cancer
- breast cancer molecular subtypes
- multigene assays
- breast cancer prognosis
- breast cancer staging
- adjuvant chemotherapy
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