Advanced Research in Early Pregnancy Loss and Other Pregnancy Complications

Dear Colleagues,

Early pregnancy is a complex process involving a series of maternal endocrinological, metabolic, immunological, hematological, cellular, and molecular adaptations. These alternations are critical in establishing a dynamic homeostatic environment for embryo implantation, endometrium decidualization, placentation, and fetal development.

Accumulated evidence has shown that the disruption of this delicately modulated homeostasis will cause implantation failure, insufficient decidualization, and defective placentation, leading to abnormal fetal growth or even fetal demise. Clinical manifestations include biochemical pregnancy and spontaneous miscarriage primarily occurring in the first trimester of gestation, generally categorized as pregnancy loss. Correspondingly, late gestation stages may exhibit complications such as fetal growth restriction, preeclampsia, fetal death, and preterm birth.

Nearly half of pregnancy losses and associated complications remain unexplained. Tragically, many patients often experience recurrence. With recent advancements in biomedicine, omics, and molecular and single-cell techniques, growing innovations have unveiled the underlying mechanisms, particularly regarding maternal adaptations and maternal–fetal interactions. These scientific breakthroughs hold translational promise for clinical application and practice in prediction, diagnosis, monitoring, and treatment for better pregnancy outcomes, attracting great interest from clinicians, caretakers, scientists, pharmaceutical companies, patients, and their families.

This Special Issue will focus on the latest research advances and updates in early pregnancy loss and complications. We welcome high-quality studies exploring the underlying mechanisms of pregnancy loss, including studies on signaling pathways and cellular functions, animal studies, and translational studies with potential clinical applications. By consolidating diverse research perspectives, this Special Issue aims to enhance the understanding and management of these critical conditions, ultimately improving maternal–fetal health.

Prof. Dr. Chi Chiu Wang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• pregnancy loss
• miscarriage
• implantation failure
• fetal growth restriction
• preeclampsia
• fetal death
• preterm birth
• pathology
• pathogenesis
• mechanism