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Biomedicines
Special Issues
Vitamin K and Vitamin D in Health and Disease
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Vitamin K and Vitamin D in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1533

Special Issue Editors

Prof. Dr. Alexandra M. Crǎciun

E-Mail Website
Guest Editor
Department of Biochemistry, University of Medicine and Pharmacy Iuliu Hatieanu Cluj-Napoca, Cluj-Napoca, Romania
Interests: bone metabolism; vitamin D; biomedical science; cartilage arthritis; rheumatoid arthritis; bone; osteoblasts; vitamin K; atherosclerosis; bone research; clinical chemistry; clinical trials; nutritional biochemistry; bone mineral density; osteoporosis; cardiovascular risk; hip fracture; bone mineralization; myocardial infarction; calcium; metabolic syndrome; lipids; lipoproteins; cardiovascular disease; diabetes; chronic inflammation; chronic intestinal disease; microbiota; short-chain fatty acids
Special Issues, Collections and Topics in MDPI journals
Dr. Ciprian N. Silaghi

E-Mail Website
Guest Editor
Department of Medical Biochemistry, University of Medicine and Pharmacy Iuliu Hatieanu Cluj-Napoca, Cluj-Napoca, Romania
Interests: vitamin K-dependent proteins; atherosclerosis; clinical chemistry; ectopic calcifications; cardiovascular and renal diseases; metabolic syndrome; diabetes mellitus; chronic and acute inflammation; chronic bowel diseases; microbiota; short-chain fatty acids

Special Issue Information

Dear Colleagues,

The liposoluble vitamins D and K are well known to play roles in multiple processes, from calcium metabolism to immunity, to energy metabolism and cancer prevention. This Special Issue will focus on the role of vitamin D- and K-dependent proteins in diseases associated with metabolic or endocrine disbalances. In addition to providing insights into the vitamin D and K status in healthy subjects and diseases, this Special Issue will pay special attention to the regulatory effects of short-chain fatty acids, as products of the gut microbiota, on serum vitamin K-dependent proteins. Researchers are invited to share their knowledge and expertise regarding their recent research observations in this field.

Prof. Dr. Alexandra M. Crăciun
Dr. Ciprian N. Silaghi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D
  • vitamin K
  • Gla proteins
  • cardiovascular and renal diseases
  • metabolic syndrome
  • diabetes mellitus
  • chronic and acute inflammation
  • chronic bowel diseases
  • cartilage arthritis
  • rheumatoid arthritis
  • osteoblasts
  • bone research
  • atherosclerosis
  • lipids
  • lipoproteins
  • short-chain fatty acids.

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Published Papers (2 papers)

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Research

14 pages, 2335 KiB  
Article
Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients
by Sandica Bucurica, Andreea Simona Nancoff, Madalina Dutu, Mihaela Raluca Mititelu, Laura Elena Gaman, Florentina Ioniță-Radu, Mariana Jinga, Ionela Maniu and Florina Ruța
Biomedicines 2024, 12(8), 1686; https://doi.org/10.3390/biomedicines12081686 - 29 Jul 2024
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Abstract
Anomalies in lipid metabolism involve multifactorial pathogenesis, among other factors, being associated with an inflammatory state and disturbances in vitamin D status. The literature has focused on the binary relationships between inflammation and dyslipidemia, vitamin D and dyslipidemia, or vitamin D and inflammation. [...] Read more.
Anomalies in lipid metabolism involve multifactorial pathogenesis, among other factors, being associated with an inflammatory state and disturbances in vitamin D status. The literature has focused on the binary relationships between inflammation and dyslipidemia, vitamin D and dyslipidemia, or vitamin D and inflammation. Our study aimed to explore the link between all these three factors: 25-OH vitamin D serum levels, the presence of inflammation assessed through serum C-reactive protein (CRP), and serum lipid profile in 2747 hospitalized patients. Our results showed a positive correlation of HDL-C with 25 (OH) vitamin D and a negative correlation of HDL-C with CRP. This relationship had different patterns in the statistical network analysis. The network analysis patterns are preserved for males and females, except for the relationship between CRP and vitamin D, which is present in male cases and absent in females. The same triangular relationship between all three—CRP, vitamin D, and HDL-C was found with different strengths of partial correlation in obese and non-obese patients. This pattern was similar in patients with and without fatty liver. A shifted pattern was found in the network analysis of hypertensive patients. The CRP was negatively correlated with vitamin D and HDL-C, and vitamin D was positively correlated with HDL-C in non-hypertensive patients. Castelli’s Risk indexes I and II were positively associated with CRP, suggesting that increased cardiovascular risk is proportional to an inflammatory state. The triad formed by altered serum lipid levels, inflammation, and vitamin D represents a complex relationship marked by specific dynamics between lipidic fractions such as HDL-C and C-reactive protein and vitamin D. Full article
(This article belongs to the Special Issue Vitamin K and Vitamin D in Health and Disease)
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12 pages, 564 KiB  
Article
Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study
by Simona R. Gheorghe, Tamás Ilyés, Gabriela A. Filip, Ana S. Dănescu, Teodora L. Timiș, Meda Orăsan, Irina Stamate, Alexandra M. Crăciun and Ciprian N. Silaghi
Biomedicines 2024, 12(6), 1180; https://doi.org/10.3390/biomedicines12061180 - 26 May 2024
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Abstract
Psoriasis vulgaris (PV) is a disease characterized by skin manifestations and systemic inflammation. There are no published studies to date on vitamin K status assessed by extrahepatic vitamin K-dependent proteins [e.g., osteocalcin (OC) and matrix Gla protein (MGP)] in patients with PV, even [...] Read more.
Psoriasis vulgaris (PV) is a disease characterized by skin manifestations and systemic inflammation. There are no published studies to date on vitamin K status assessed by extrahepatic vitamin K-dependent proteins [e.g., osteocalcin (OC) and matrix Gla protein (MGP)] in patients with PV, even if vitamin K was found to promote wound contraction and decrease the healing time of the skin. Metabolic syndrome (MS), a comorbidity of PV, was found to influence vitamin K status, and vitamin D was found to be involved in the pathogenesis of PV. Therefore, our aim was to assess the status of vitamins K and D in subjects with PV. We enrolled 44 patients with PV and 44 age- and sex-matched subjects as a control group (CG), of which individuals with MS were designated the CG with MS subgroup. Furthermore, the PV patients were stratified into two subgroups: those with MS (n = 20) and those without MS (n = 24). In addition to the quantification of vitamin D and MGP in all subjects, the uncarboxylated OC/carboxylated OC (ucOC/cOC) ratio was also assessed as an inversely proportional marker of vitamin K status. We found an increased ucOC/cOC ratio in the PV group compared to CG but also a greater ucOC/cOC ratio in the PV with MS subgroup than in the CG with MS subgroup. MGP was decreased in the PV with MS subgroup compared to CG with MS subgroup. There was no difference in the vitamin D concentration between the groups. This is the first study to report decreased vitamin K status in patients with PV, independent of the presence of MS. Full article
(This article belongs to the Special Issue Vitamin K and Vitamin D in Health and Disease)
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