Molecular Mechanisms and Therapy for Heart Valve Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2228
Special Issue Editors
Interests: atherosclerosis; valve heart disease; biomarkers; cell signalling; molecular biology; ncRNAs; epigenetics; therapeutics; cardiovascular biology; tissue engineering
Interests: valve heart disease; aortic stenosis; diabetes; atherosclerosis; renal disease; α-Klotho; ageing; epigenetics; molecular biology; cell signalling
Interests: vascular aging; sex differences; therapeutic targets; cell crosstalk; cardiovascular diseases; vascular stiffness; epigenetics
Special Issue Information
Dear Colleagues,
Heart valve disease (HVD) is a major form of cardiovascular disease and is strongly prevalent in the elderly. Owing to the continuum ageing of the population, HVD is anticipated to become the next cardiac epidemic. With long preclinical stages, the onset of symptoms stands as a poor prognosis marker. After more than 30 years of research we have now some clues on how the valves are damaged. Highly multifactorial and complex cues trigger molecular, cellular, and interstitial events. Resident valvular cells, and others recruited within the damaged valve, are pivotal to the HVD. Nevertheless, identifying druggable targets is yet an unmet clinical need and valvular replacement remains the current therapeutic choice, regardless of limitations. Moreover, accumulating evidence suggest sex-related differences underlying the pathogenesis of HVD, seemingly impacting the clinical prognosis and management of the patients. Yet, female sex remains overlooked. Revisiting our current knowledge in HVD is strongly advised.
In the era of multi-omics and high-throughput pharmacological screenings, a spike of novel targets, biomarkers, and drugs are expected. It is our task to identify, standardize, and implement appropriate HVD models and clinical studies for target validation and drug testing. The aim of this Special Issue is to gather interdisciplinary, meaningful, and provoking research contributions (e.g., basic, translational, or clinical) on molecular and cellular mechanisms, novel therapies, and diagnosis/prognosis tools in HVD. A special focus, but not exclusive, will be given to the study of sex-related differences in HVD. Original research, brief research, methodological studies, and reviews are welcomed.
Dr. Eva Jover García
Dr. Ernesto Martín-Núñez
Dr. Jaime Ibarrola
Guest Editors
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Keywords
- valvular heart disease
- sexual dimorphism
- experimental modelling
- cell signalling
- molecular biology
- epigenetics
- biomarkers
- diagnostics
- tissue engineering
- therapeutics
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