Transcriptional Regulation, Chromatin Structure Changes and Cell Cycle Control in Hypoxia
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 305
Special Issue Editor
Interests: hypoxia; inflammation; HIF; NF-kappaB; cancer; transcription; epigenetics; cell cycle; PHDs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A reduction in oxygen availability, or hypoxia, plays important roles in physiological processes and also plays a role in the pathology of many human diseases. Hypoxia results in the activation of a number of different responses both at the whole organism and the cellular level. To achieve these responses, cells rely on changes in gene expression and metabolism. Hypoxia inducible factors (HIFs) stand at the centre of most of hypoxia-induced responses, coordinating activation of a vast number of oxygen homeostatic genes. However, for HIF to be effective, additional changes, most of which are HIF-independent, must occur. These changes are mainly mediated by 2-oxoglutarate and iron-dependent dioxygenases. This review and research article series will focus on HIF and HIF-dependent pathways elicited by hypoxia, mechanisms altering the cell cycle and metabolism, and how chromatin is altered in response to these changes in cells and organisms. It will also include potential therapeutic applications for such pathways in a number of human diseases.
This Special Issue is jointly organized between the journals IJMS and Biomedicines. According to the Aims and Scope of these journals, articles showing basic studies in biochemistry, molecular biology, and molecular medicine can be submitted to IJMS, while articles presenting a more clinical content can be submitted to Biomedicines.
Prof. Dr. Sonia Rocha
Guest Editor
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Keywords
- hypoxia
- cell cycle
- chromatin
- dioxygenases
- PHDs
- JmjCs
- TETs
- HIFs
- transcription
- chromatin remodellers
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