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Biomedicines
Special Issues
Hydra, Polyps, Medusae: Model Organisms in Biomedical Research
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Hydra, Polyps, Medusae: Model Organisms in Biomedical Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1164

Special Issue Editor

Dr. Paola Pierobon

E-Mail Website
Guest Editor
Institute of Applied Sciences and Intelligent Systems E. Caianiello, CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Interests: neurobiology; hydra

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to present articles that investigate cellular, molecular, and circuit mechanisms relevant to human health. Papers should address novel aspects of stem cell biology, regenerative biology, host-bacterial, interactions, and the toolkit of cell signaling: messengers, channels, and receptors. A comparative approach based on additional model systems such as Hydra and/or other cnidarian species is recommended.

Dr. Paola Pierobon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regeneration
  • development
  • microbiome
  • ion channels
  • receptors
  • environment

Published Papers (1 paper)

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Research

36 pages, 20306 KiB  
Article
The Wnt/β-catenin/TCF/Sp5/Zic4 Gene Network That Regulates Head Organizer Activity in Hydra Is Differentially Regulated in Epidermis and Gastrodermis
by Laura Iglesias Ollé, Chrystelle Perruchoud, Paul Gerald Layague Sanchez, Matthias Christian Vogg and Brigitte Galliot
Biomedicines 2024, 12(6), 1274; https://doi.org/10.3390/biomedicines12061274 - 8 Jun 2024
Viewed by 811
Abstract
Hydra head formation depends on an organizing center in which Wnt/β-catenin signaling, that plays an inductive role, positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter drives eGFP [...] Read more.
Hydra head formation depends on an organizing center in which Wnt/β-catenin signaling, that plays an inductive role, positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter drives eGFP expression in either the epidermis or gastrodermis, we show that Sp5 promoter activity is differentially regulated in each epithelial layer. In intact animals, epidermal HySp5:GFP activity is strong apically and weak along the body column, while in the gastrodermis, it is maximal in the tentacle ring region and maintained at a high level along the upper body column. During apical regeneration, HySp5:GFP is activated early in the gastrodermis and later in the epidermis. Alsterpaullone treatment induces a shift in apical HySp5:GFP expression towards the body column where it forms transient circular figures in the epidermis. Upon β-catenin(RNAi), HySp5:GFP activity is down-regulated in the epidermis while bud-like structures expressing HySp5:GFP in the gastrodermis develop. Sp5(RNAi) reveals a negative Sp5 autoregulation in the epidermis, but not in the gastrodermis. These differential regulations in the epidermis and gastrodermis highlight the distinct architectures of the Wnt/β-catenin/TCF/Sp5/Zic4 network in the hypostome, tentacle base and body column of intact animals, as well as in the buds and apical and basal regenerating tips. Full article
(This article belongs to the Special Issue Hydra, Polyps, Medusae: Model Organisms in Biomedical Research)
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