Role of Inflammasomes in Health and Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2319
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammasomes are a topic of growing interest today, as they are biologic entities transversely implicated in the pathogenesis of many acute and chronic inflammation-related diseases. The constitution and cleavage actions of such multi-protein complexes underlie the functioning of the innate response to various inflammatory stimuli. The final result is a particular form of programmed cell death, namely, pyroptosis. In the absence of relevant disorders, inflammasomes such as NLRP3, NAIP/NLRC4, and others act as intracellular ‘sensors’ of exogenous or endogenous aggressions via PAMPs and DAMPs. In autoimmune and oncohaematological diseases, they are perpetually involved and might feed mechanisms of clinical aggravation and progression. Interestingly, there is an undeniable signaling crosstalk linking cytokines activated by inflammasomes to injury-response mechanisms such as coagulation and fibrosis. Recently, inflammasomes have also attracted the attention of researchers because of their relevance in causing acute alveolar damage during SARS-CoV-2 infection. Silencing or mitigating aberrant over-functioning of these complexes could be a turning point for several pathological conditions. For this reason, targeted therapies that may interfere with inflammasome signaling deserve to be thoroughly developed. This Special Issue aims to bring together the main scientific proposals on the subject, covering everything from normal pathophysiology to the most recent clinical and translational findings in inflammatory diseases.
Dr. Alessandro Lucchesi
Guest Editor
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Keywords
- inflammasome
- inflammation
- autoimmunity
- haematology
- caspase
- cytokine
- cell death
- COVID-19
- infection
- innate immunity
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