NLRP3 Inflammasome and Inflammatory Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2614
Special Issue Editors
Interests: inflammation; inflammasome; NLRP3; Gasdermin; gastrointestinal cancers; viral vectors, signaling pathways; genome editing; light and electron microscopy; protein and nucleic acids quantification and analysis; flow-cytometer and cell sorting; cell death assay; immune cell isolation from tissue/biopsy; TRIM-away system; RNAi; cloning; gene overexpression; Elisa; cell biology; intracellular ion fluxes
Interests: inflammation; innate immunity; pattern-recognition receptors; higher-ordered mac-romolecular assemblies; inflammasomes; NLRP3; inflammation-associated disor-ders; structural biology; cryo-electron microscopy; X-ray crystallography; protein biochemistry; cell biology
Interests: oncology; cancer development and progression; inflammation cancer-related; in-flammasome; cell biology; cancer signaling pathways; immunohistochemistry and immunofluorescence; gene expression
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Special Issue Information
Dear Colleagues,
Innate immunity embraces different strategies to overcame potential pathogenic insults. Among them, the NLRP3 inflammasome is emerging as one of the most effective response to sterile and/or microbial dangers in the gastrointestinal tract. NLRP3 pathway involves a cytosolic multi-protein complex, which, upon trigger recognition, it assembles, leading to the activation of caspase-1. Once activated, caspase-1 mediates the maturation of the pro-inflammatory cytokines, pro-IL-1β and IL-18, into their bioactive form (IL-1β and IL-18) as well as the activation of the membrane pore-forming protein gasdermin D, allowing the release of the cytokines into the stream, concomitantly with an inflammatory form of cell death called pyroptosis, thus, providing, in most cases, protection against bacterial and viral infections. However, while NLRP3 inflammasome activation is deleterious in the pathogenesis of inflammatory and metabolic diseases, it has been recently shown that its hyperactivation plays beneficial contributions in numerous gastrointestinal inflammatory-driven diseases, including cancer, as well. It becomes, therefore, crucial a fine tuning of NLRP3 inflammasome activation for maintaining proper cellular homeostasis and health.
Dr. Roberto Negro
Dr. Liudmila Andreeva
Dr. Concetta Saponaro
Guest Editors
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Keywords
- inflammasome
- NLRP3
- Gasdermins
- pyroptosis
- inflammation
- cancer
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