New Perspectives on Chronic Kidney Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 273

Special Issue Editor


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Guest Editor
Department of Nephrocardiology, Medical University of Lodz, ul. Żeromskiego 113, 90-549 Lodz, Poland
Interests: nephrology; chronic kidney disease

Special Issue Information

Dear Colleagues,

The kidney is a vital organ in the human body, responsible for filtering waste products and excess fluids from the blood, producing urine as a result. Located on either side of the spine in the retroperitoneum, the kidneys also play a crucial role in regulating electrolyte levels, blood pressure, and the production of red blood cells. Each kidney contains around one million nephrons, the functional units responsible for filtration. Each nephron includes a renal corpuscle and a renal tubule, with segments such as the proximal convoluted tubule, loop of Henle, distal convoluted tubule, and connecting tubule.

Chronic kidney disease is a progressive condition that affects more than 10% of the general population worldwide. Early detection plays a critical role in preventing the onset of kidney failure. Physicians assess patients for indicators of renal disease and perform a range of diagnostic tests to evaluate kidney function, including measurements such as serum creatinine level, cystatin C, blood urea nitrogen, glomerular filtration rate (eGFR), electrolyte levels, and red blood cell count, as well as urinalysis. On occasion, a biopsy of kidney tissue may be required for accurate diagnosis. To date, these tests have represented the standards for the diagnostics of kidney diseases. However, new technologies offer promising new ways to diagnose and prognose kidney diseases. Biomarkers other than plasma creatinine and the glomerular filtration rate are becoming crucial for the diagnosis and assessment of a patient’s condition. New diagnostic methods play a significant role in diagnosis and provide greater treatment options.

The aim of this Special Issue is to present recent advances in chronic kidney disease.

Both original research articles and reviews from the entire nephrology community are welcome.

Dr. Ewelina Młynarska
Guest Editor

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Keywords

  • chronic kidney disease
  • SGLT2 inhibitors
  • diabetic kidney disease
  • acute kidney injury
  • hemodialysis
  • electrolytes
  • biopsy
  • nephron

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Published Papers (1 paper)

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Research

12 pages, 757 KiB  
Article
Inflammation and Vitamin D Receptor Polymorphism: Impact on All-Cause and Cardiovascular Mortality in Mexican Women on Dialysis
by Marcela Ávila, Carmen Mora, Ma del Carmen Prado-Uribe, Alfonso Cueto-Manzano, Abdul Rashid Qureshi, Bengt Lindholm, Alma Sofía Bernal Amador and Ramón Paniagua
Biomedicines 2024, 12(9), 1990; https://doi.org/10.3390/biomedicines12091990 (registering DOI) - 2 Sep 2024
Abstract
Mineral bone disease (MBD) is common in dialysis patients. Genetics and the hormonal environment influence the clinical picture and outcomes of women. This study aimed to determine how these factors affect mortality. In 234 female dialysis patients on Continuous Ambulatory (48%) or Automated [...] Read more.
Mineral bone disease (MBD) is common in dialysis patients. Genetics and the hormonal environment influence the clinical picture and outcomes of women. This study aimed to determine how these factors affect mortality. In 234 female dialysis patients on Continuous Ambulatory (48%) or Automated (29%) Peritoneal Dialysis or Hemodialysis (23%), MBD biochemical variables, as well as bone density and genetic Bsm1 polymorphism of vitamin D receptor (VDR) were performed at baseline. The cohort was followed-up by 17 (IQ range 15–31) months. According to VDR polymorphism, the distribution of patients was bb: 64% and BB+Bb: 36%. Fifty-five patients died from all-cause mortality; the hs-C-reactive protein level was the most significant risk in multivariate Cox analysis. Nineteen died from cardiovascular mortality. None of the variables were significant for cardiovascular mortality. Patients with bb plus inflammation had the highest risk in the analysis; the significance persisted after adjustment for age, diabetes, and parathyroid hormone levels HR 2.33 (95% CI, 1.01–8.33) and after further adjustment for time on dialysis, albumin, and Osteoprotegerin levels HR 3.49 (95% CI, 1.20–10.9). The presence of the bb genotype from VDR and inflammation had the highest risk of death from all-cause mortality in females on CAPD, APD, and HD patient. Full article
(This article belongs to the Special Issue New Perspectives on Chronic Kidney Disease)
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