Advancing Precision Radiation Oncology in Head and Neck Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 872
Special Issue Editor
Interests: radiotherapy; oncology; immunotherapy; radiomics; oncogenetics; proton therapy
Special Issue Information
Dear Colleagues,
This Special Issue, "Advancing Precision Radiation Oncology in Head and Neck Cancers," will highlight the latest translational and clinical advances driving personalized radiotherapy for head and neck malignancies. Head and neck cancers, particularly squamous cell carcinoma, exhibit significant biological and molecular heterogeneity, which impacts treatment response and outcomes. Recent research has elucidated the roles of the tumor microenvironment, DNA damage response pathways, and immune modulation in radioresistance, offering new targets for radiosensitization and combination therapies.
Precision radiation oncology leverages genomic, transcriptomic, and imaging biomarkers to tailor treatment plans, moving beyond the traditional one-size-fits-all approach. Innovations such as the radiosensitivity index and radiomics enable non-invasive, longitudinal assessment of tumor biology and heterogeneity, facilitating adaptive and individualized therapy. Genomically guided radiation therapy is increasingly recognized as essential for improving outcomes and minimizing toxicity, as emphasized by the American Society for Radiation Oncology, the American Association of Physicists in Medicine, and the National Cancer Institute.
This Special Issue will feature original research, reviews, and expert perspectives on molecular profiling, biomarker-driven treatment adaptation, novel radiosensitizers, and informatics infrastructure for precision medicine in radiation oncology. The goal is to accelerate the integration of precision strategies into routine clinical practice, ultimately improving survival and quality of life for patients with head and neck cancers.
Dr. Wing-Keen Yap
Guest Editor
Manuscript Submission Information
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Keywords
- precision radiation oncology
- head and neck cancers
- oncogenetics
- genomic biomarkers
- radiosensitivity
- adaptive radiotherapy
- artificial intelligence
- immunotherapy integration
- proton therapy
- deescalation strategies
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