Advances in “Bed and Bench” Research for Head and Neck Cancer

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1732

Special Issue Editors


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Guest Editor
Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Interests: head and neck cancer; HPV; EBV; immunotherapy; biomarker; cancer metabolism; novel therapeutic strategies; lipid; micro-RNA; quality of life; real-world evidence; epidemiology

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Guest Editor
1. Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan
2. Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan
3. School of Traditional Chinese Medicine, Chang Gung University, Taoyuan City, Taiwan
Interests: head and neck cancer; immunotherapy; biomarker; cancer metabolism; novel therapeutic strategies

Special Issue Information

Dear Colleagues,

Head and neck cancer (HNC) is one of the most common malignant tumors with the characteristics of strong invasive ability, lymph node metastasis and high recurrence rate. In fact, despite recent advances in diagnosis and treatment, prognosis remains poor. A better understanding of the mechanisms involved in cancer behavior (“bench” studies) may lead to the identification of new potential therapeutic targets. Recent advances in clinical research that assesses the need for treatment strategies and new therapies also contribute to a better understanding of HNC-related quality of life and real-world evidence (“bed” studies).

This Special Issue aims to cover new insights from head and neck cancer "bed and bench" research, including big data analysis or multi-institutional cohort studies, molecular markers or omics profiling, etc. Original and review articles are welcome to enrich the literature and the scientific communities.

Dr. Sheng Dean Luo
Dr. Yu-Ming Wang
Guest Editors

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Published Papers (1 paper)

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Research

11 pages, 542 KiB  
Article
Worsening Rhinosinusitis as a Prognostic Factor for Patients with Nasopharyngeal Carcinoma: A Retrospective Study
by Wei-Chieh Lin, Yu-Hung Kuo, Chuan-Jen Hsu, Hung-Pin Wu and Yuan-Jhen Hsu
Biomedicines 2022, 10(12), 3235; https://doi.org/10.3390/biomedicines10123235 - 13 Dec 2022
Viewed by 1373
Abstract
Rhinosinusitis is common in patients with nasopharyngeal carcinoma (NPC). Our study aimed to explore the role of rhinosinusitis severity in NPC prognosis. Medical records and radiologic examinations of 90 patients with NPC at a single medical center from 2009–2016 were retrospectively analyzed. The [...] Read more.
Rhinosinusitis is common in patients with nasopharyngeal carcinoma (NPC). Our study aimed to explore the role of rhinosinusitis severity in NPC prognosis. Medical records and radiologic examinations of 90 patients with NPC at a single medical center from 2009–2016 were retrospectively analyzed. The Lund–Mackay (L–M) score was obtained for each patient before and after 6 months of treatment. Rhinosinusitis diagnosis was based on L–M scores of ≥4. L–M score differences were calculated as pre-treatment rhinosinusitis (PRRS) minus post-treatment rhinosinusitis (PSRS). L–M score difference was sub-grouped into “L–M scores > 0”, “L–M scores = 0”, and “L–M scores < 0”. Clinical staging of our patients based on the American Joint Committee on Cancer 7th edition were: stage I in nine, stage II in seventeen, stage III in twenty-two, and stage IV in forty-two patients; twenty-seven (30%) patients had died. PRRS incidence was 34.4%, and PSRS was 36.7%. Median of L–M scores difference was 0 (−2.2). L–M score difference was an independent prognostic factor for the overall survival of patients with NPC (p < 0.05). Therefore, worsening rhinosinusitis was a prognostic factor for patients with NPC. Clinicians should consider NPC as a warning sign of poor prognosis during routine follow-ups. Full article
(This article belongs to the Special Issue Advances in “Bed and Bench” Research for Head and Neck Cancer)
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