Nano-Drug Delivery for Cancer Treatment

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2434

Special Issue Editor


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Guest Editor
Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Interests: nanotechnology; biomaterials; cancer treatment; drug delivery

Special Issue Information

Dear Colleagues,

The field of drug delivery concerned with directing and augmenting the effects of agents used in anti-neoplastic therapy has produced several technologies which are now in clinical use. As the field continues to produce useful products, research in useful materials, as well as their creation, properties, and application, will drive the next generation of therapeutics.

Stages of this development pipeline begin with creation of novel materials that can be scaled to nano-delivery systems, or with the re-application of established systems engineered with novel mechanisms to improve their application to a wider range of payloads or targets. The next stage of the pipeline explores the therapeutic properties of these delivery systems when they specifically accumulate in a targeted cancer environment, or the side effects when they non-specifically accumulate in off-target sites. The final stage of the pipeline explores the overall therapeutic efficacy of these delivery systems—either front-line, or in disease that has no established treatment. The aim of this Special Issue is to celebrate work in development through all stages of this development pipeline in the form of original research or review articles.

Dr. Jason S. Buhrman
Guest Editor

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Keywords

  • biomaterials
  • drug delivery
  • selective accumulation
  • payload release

Published Papers (1 paper)

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Review

15 pages, 1172 KiB  
Review
Evaluation of Folate-Functionalized Nanoparticle Drug Delivery Systems—Effectiveness and Concerns
by Muhammad Aiman Irfan Ibrahim, Rozana Othman, Chin Fei Chee and Faisalina Ahmad Fisol
Biomedicines 2023, 11(7), 2080; https://doi.org/10.3390/biomedicines11072080 - 24 Jul 2023
Cited by 3 | Viewed by 1874
Abstract
Targeting folate receptors is a potential solution to low tumor selectivity concerning conventional chemotherapeutics. Apart from antibody–drug conjugates, folate-functionalized nanoparticle drug delivery systems are interesting to be explored due to many advantages, yet currently, none seems to enter the clinical trials. Multiple in [...] Read more.
Targeting folate receptors is a potential solution to low tumor selectivity concerning conventional chemotherapeutics. Apart from antibody–drug conjugates, folate-functionalized nanoparticle drug delivery systems are interesting to be explored due to many advantages, yet currently, none seems to enter the clinical trials. Multiple in vitro evidence is available to support its efficacy compared to the non-targeting carrier and free drug formulation. Additionally, several studies pointed out factors affecting its effectiveness, including surface properties and endosomal trapping. However, in vivo biodistribution studies revealed issues that may arise from folate receptor targeting, including rapid liver uptake, subsequently reducing the nanoparticles’ tumor uptake. This issue may be due to the folate receptor β expressed by the activated macrophages in the liver; route of administration and tumor location might also influence the targeting effectiveness. Moreover, it is perplexing to generalize nanoparticles reported from various publications, primarily due to the different formulations, lack of characterization, and experimental settings, making it harder to determine the accurate factor influencing targeting effectiveness. Full article
(This article belongs to the Special Issue Nano-Drug Delivery for Cancer Treatment)
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