Molecular Research of Neuroinflammation and Neurogenesis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2497

Special Issue Editor


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Guest Editor
Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu City 30013, Taiwan
Interests: animal behaviors; emotion; biotechnology; neurogenetics

Special Issue Information

Dear Colleagues,

The nature of neurogenesis and its integration into a functional circuit is more complex than for other cells. We are relatively certain that widespread differences in neurogenesis, such as larger brain sizes in males than females, larger eye sizes in females than males, and a higher neurogenesis in young individuals, have become accepted in this field. As illustrated in the beautiful drawings of Santiago Ramon y Cajal of the brain, we are equally sure that it is only possible in some individuals for the consequences of neurogenesis to lead to illness or mortality. Together, we must test the concept of differences in neurogenesis as a disease neuropathology and illustrate the idea of neurogenesis as evolutionary constrained, genetical organized developmental processes emerge from a wide range of studies, including neurogenetics and neurobiology. In this Special Issue, we welcome papers that focus on molecular biology and treatments of diseases, which aid in understanding the importance of both basic neurogenesis and clinical-related disease treatment studies:

  • Neuroinflammation and neurogenesis;
  • Neurogenesis and brain glial cells and microglia;
  • Neurogenesis and neurodegeneration.

Dr. Hui-Yun Chang
Guest Editor

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Keywords

  • neuroinflammation
  • neurogenesis
  • brain development
  • basic neurogenesis
  • neurobiology
  • neurogenetics

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Published Papers (1 paper)

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Research

22 pages, 5214 KiB  
Article
Enriched Environment Induces Sex-Specific Changes in the Adult Neurogenesis, Cytokine and miRNA Expression in Rat Hippocampus
by Anna Vinogradova, Maria Sysova, Polina Smirnova, Maria Sidorova, Andrei Turkin, Ekaterina Kurilova and Oksana Tuchina
Biomedicines 2023, 11(5), 1341; https://doi.org/10.3390/biomedicines11051341 - 2 May 2023
Cited by 2 | Viewed by 2183
Abstract
An enriched environment stimulates adult hippocampal plasticity, but the exact cellular and molecular mechanisms are complex, and thus a matter of debate. We studied the behavior and hippocampal neurogenesis in adult male and female Wistar rats that were housed in an enriched environment [...] Read more.
An enriched environment stimulates adult hippocampal plasticity, but the exact cellular and molecular mechanisms are complex, and thus a matter of debate. We studied the behavior and hippocampal neurogenesis in adult male and female Wistar rats that were housed in an enriched environment (EE) for two months. Both EE males and females performed better than control animals in a Barnes maze, meaning that EE enhances spatial memory. However, the expression levels of neurogenesis markers KI67, DCX, Nestin, and Syn1 increased only in EE females, while in EE males only KI67 and BDNF were higher than in the corresponding control. The number of DCX+ neurons on brain slices increased in the dentate gyrus of EE females only, i.e., the level of adult hippocampal neurogenesis was increased in female but not in male rats. The level of anti-inflammatory IL-10 and signaling pathway components was upregulated in EE females. Of 84 miRNAs tested, in the hippocampi of EE female rats we detected upregulation in the expression levels of 12 miRNAs related to neuronal differentiation and morphogenesis, while in EE males four miRNAs were upregulated and involved in the regulation of cell proliferation/differentiation, and one was downregulated and associated with the stimulation of proliferation. Taken altogether, our results point to sex-specific differences in adult hippocampal plasticity, IL-10 expression, and miRNA profiles induced by an enriched environment. Full article
(This article belongs to the Special Issue Molecular Research of Neuroinflammation and Neurogenesis)
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