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Biomedicines
Special Issues
Ovarian Endometriosis: From Molecular Mechanism to Therapeutic Perspectives
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Ovarian Endometriosis: From Molecular Mechanism to Therapeutic Perspectives

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2929

Special Issue Editor

Prof. Dr. Wei-Chung Yang

E-Mail Website
Guest Editor
The PhD Program for Translational Medicine, Taipei Medical University, Taipei, Taiwan
Interests: matrix biology; protein engineering; proteoglycan; biochemistry; translational medicine

Special Issue Information

Dear Colleagues,

Endometriosis affects 10% of women at the reproductive age. Severe endometriosis could cause infertility in women. Ovarian endometriosis (endometrioma) with genetic changes may develop into ovarian cancer. The diagnosis of endometriosis is delayed for 8–10 years due to the lack of reliable and sensitive biomarkers for non-invasive diagnosis. Additionally, there is no curable treatment for endometriosis. This Special Issue will include novel findings at the molecular level to understand the disease development and progression for the development of efficient non-invasive diagnosis and treatment of endometriosis.

Prof. Dr. Wei-Chung Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • endometrioma
  • ovarian endometriosis
  • biomarker discovery
  • therapy
  • non-invasive diagnosis

Published Papers (1 paper)

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Review

16 pages, 2092 KiB  
Review
The Double Engines and Single Checkpoint Theory of Endometriosis
by Che-Fang Hsu, Aye Aye Khine, Hsuan-Shun Huang and Tang-Yuan Chu
Biomedicines 2022, 10(6), 1403; https://doi.org/10.3390/biomedicines10061403 - 14 Jun 2022
Cited by 3 | Viewed by 2472
Abstract
Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten women. This disease is difficult to diagnose early, it [...] Read more.
Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten women. This disease is difficult to diagnose early, it is prone to dissemination, is difficult to eradicate, tends to recur, and is regarded as “a cancer of no kill”. Indeed, the development of endometriosis closely resembles that of cancer in the way of mutagenesis, pelvic spreading, and immunological adaptation. While retrograde menstruation has been regarded as the primary cause of endometriosis, the role of ovulation and menstrual stimuli in the development of endometriosis has long been overlooked. The development of ovarian and peritoneal endometrioses, similar to the development of high-grade serous carcinoma in the fallopian tube fimbriae with intraperitoneal metastasis, depends highly on the carcinogens released during ovulation. Moreover, endometriosis carries an extremely hypermutated genome, which is non-inferior to the ultra-mutated endometrial cancer. The hypermutation would lead to an overproduction of new proteins or neoantigens. Because of this, the developing endometriosis may have to turn on the PD-1/PDL-1 “self-tolerance” checkpoint to evade immune surveillance, leaving an Achilles tendon for an immune checkpoint blockade. In this review, we present the double engines and single checkpoint theory of the genesis of endometriosis, provide the current pieces of evidence supporting the hypothesis, and discuss the new directions of prevention and treatment. Full article
(This article belongs to the Special Issue Ovarian Endometriosis: From Molecular Mechanism to Therapeutic Perspectives)
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