Mechanisms and Pharmacological Targets for Pain

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 981

Special Issue Editor


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Guest Editor
Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA
Interests: pain; inflammation; pharmacology; drug discovery

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Mechanisms and Pharmacological Targets for Pain", aims to delve into the complex biological and molecular underpinnings of pain, a pervasive and often debilitating symptom affecting millions worldwide. This Special Issue will cover the diverse mechanisms involved in pain perception and transmission, from peripheral nociceptor activation to central nervous system processing. It will explore the latest research on inflammatory, neuropathic, and chronic pain conditions, highlighting the role of various cellular and molecular players such as ion channels, neurotransmitters, and cytokines. Additionally, this Special Issue will focus on identifying and evaluating novel pharmacological targets for pain management. It will include studies on new analgesic drugs, advancements in targeted therapies, and innovative delivery systems aimed at enhancing efficacy and reducing side effects. This Special Issue will also address the challenges and opportunities of translating preclinical findings into clinical practice. By bringing together cutting-edge research and expert insights, this Special Issue seeks to advance our understanding of pain mechanisms and foster the development of more effective and safer pain treatments.

Dr. Renan F. do Espírito-Santo
Guest Editor

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Keywords

  • drug discovery
  • chronic pain
  • inflammatory pain
  • mechanisms of action
  • pain pharmacology
  • immunomodulation
  • neuropathic pain

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Published Papers (1 paper)

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Review

14 pages, 300 KiB  
Review
Post-Traumatic Trigeminal Neuropathic Pain: A Narrative Review of Understanding, Management, and Prognosis
by Hyun-Jeong Park, Jong-Mo Ahn and Ji-Won Ryu
Biomedicines 2024, 12(9), 2058; https://doi.org/10.3390/biomedicines12092058 - 10 Sep 2024
Abstract
This study provides an updated overview of the clinical characteristics of post-traumatic trigeminal neuropathic pain (PTNP) resulting from dental procedures or facial trauma, addressing its etiology, prevalence, evaluation, management, and prognosis. PTNP arises from injury to the trigeminal nerve, which governs sensory and [...] Read more.
This study provides an updated overview of the clinical characteristics of post-traumatic trigeminal neuropathic pain (PTNP) resulting from dental procedures or facial trauma, addressing its etiology, prevalence, evaluation, management, and prognosis. PTNP arises from injury to the trigeminal nerve, which governs sensory and motor functions in the maxillofacial region. The prevalence and characteristics of PTNP vary considerably across studies, with a reported prevalence ranging from 1.55% to 13%. The predominant causative factors are dental procedures, particularly third molar removal and implant placement. While gender distribution varies, a trend towards higher incidence in females is observed, particularly within the 40–60-year age group. Anatomically, the mandibular nerve is frequently involved. PTNP presents with a spectrum of symptoms ranging from tingling sensations to severe pain. Diagnostic challenges arise due to the lack of standardized criteria and potential overlap with focal neuralgia, necessitating comprehensive evaluation. Misdiagnosis can lead to prolonged patient suffering and unnecessary interventions. Successful management hinges on prompt diagnosis and interdisciplinary collaboration, with early intervention crucial in mitigating progression to chronic pain. Although nerve recovery post-trauma is challenging, preventive measures through accurate evaluation and treatment are paramount. Management strategies for PTNP include non-invasive and surgical interventions, with non-invasive approaches encompassing systemic and local pharmacological management. This narrative review aims to enhance uniformity in PTNP evaluation and treatment approaches, ultimately improving patient care and outcomes. Full article
(This article belongs to the Special Issue Mechanisms and Pharmacological Targets for Pain)
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