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Biomedicines
Special Issues
Advanced Research in Peripheral Nerve Regeneration
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Advanced Research in Peripheral Nerve Regeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4691

Special Issue Editor

Dr. Stefania Raimondo

E-Mail Website1 Website2
Guest Editor
1. Department of Clinical and Biological Sciences (DSCB), University of Torino, Orbassano, TO, Italy
2. Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Orbassano, TO, Italy
Interests: peripheral nerve; regenerative medicine; biomaterials; morphology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peripheral nerves are frequently subject to traumas and diseases.  Their injury lead to a decreased or a complete loss of sensitivity and/or motor activity and, even if peripheral nerve fibers retain a considerable regeneration potential, the functional recovery is usually rather poor. Since to date there is no optimal solution for addressing this problem, the research in the field is constantly growing.

This Special Issue "Advance Research in Peripheral Nerve Regeneration" aims to collect high-quality research articles and review articles on the latest advances in peripheral nerve regeneration research.  Articles can be focused on basic science studies of the regenerative processes (e.g. cellular and molecular mechanisms), on new strategies for improving peripheral nerve regeneration (e.g. gene therapy approaches, delivery of growth factors, secretome, cell transplantation, electrical/magnetic stimulation, phototherapy), on innovative reconstructive techniques for repairing injured peripheral nerves (e.g. tissue engineering, biomaterial scaffolds, new microsurgical techniques, nanotechnologies), on treatments for improving functional recovery ). Moreover, articles about technical aspects important for the analysis of the regeneration outcome will be welcome. Articles may include basic science and pre-clinical studies in this field.

Dr. Stefania Raimondo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • peripheral nerve
  • injury
  • repair strategies
  • regeneration
  • biological processes
  • cellular and molecular mechanisms
  • microsurgery
  • therapy
  • biomaterials

Published Papers (2 papers)

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Research

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12 pages, 1864 KiB  
Article
Enlargement of the Nerve Fibers of Silenced Lumbosacral Motoneurons in Cats
by Tessa Gordon, Lynn Eldridge and Saljae Aurora
Biomedicines 2022, 10(10), 2622; https://doi.org/10.3390/biomedicines10102622 - 18 Oct 2022
Viewed by 1391
Abstract
Whether neuromuscular activity influences the size of motor nerves is controversial. All neuromuscular activity in cat hindlimbs was eliminated by spinal cord isolation (SCI), namely, spinal cord transection above and below the medial gastrocnemius (MG) and soleus (SOL) motoneuron pools and L5-S3 dorsal [...] Read more.
Whether neuromuscular activity influences the size of motor nerves is controversial. All neuromuscular activity in cat hindlimbs was eliminated by spinal cord isolation (SCI), namely, spinal cord transection above and below the medial gastrocnemius (MG) and soleus (SOL) motoneuron pools and L5-S3 dorsal root transection. MG, SOL and sural (SUR) nerves were removed for size measurements, eight months after SCI surgery and from age-matched control cats. Nerve fiber number, the linear relationship between axon size and myelin thickness, and the bimodal distributions of nerve fiber area and diameter were maintained in all three nerves after SCI. The distributions of myelinated sensory fibers were unchanged in SUR nerves in contrast to the myelinated motor fibers in the MG and SOL nerves that were significantly larger. These findings provide evidence that all lumbar motoneurons survive SCI and that their nerve fibers enlarge. Thus, motor nerve fiber size in addition to the properties of the motoneurons and their muscle fibers is dynamic, responding to neuromuscular activity. Full article
(This article belongs to the Special Issue Advanced Research in Peripheral Nerve Regeneration)
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17 pages, 2152 KiB  
Systematic Review
The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury
by Henrik Lauer, Cosima Prahm, Johannes Tobias Thiel, Jonas Kolbenschlag, Adrien Daigeler, David Hercher and Johannes C. Heinzel
Biomedicines 2022, 10(8), 1878; https://doi.org/10.3390/biomedicines10081878 - 3 Aug 2022
Viewed by 2437
Abstract
The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery [...] Read more.
The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data. Full article
(This article belongs to the Special Issue Advanced Research in Peripheral Nerve Regeneration)
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