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Biomedicines
Special Issues
Parkinson’s Disease: From Pathophysiology to Novel Therapeutic Approaches—Second Edition
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Parkinson’s Disease: From Pathophysiology to Novel Therapeutic Approaches—Second Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2302

Special Issue Editor

Dr. Sujung Yeo

E-Mail Website
Guest Editor
College of Korean Medicine, Sang Ji University, Wonju 26339, Republic of Korea
Interests: parkinson’s disease; alpha-synuclein; dopaminergic neuron; apoptosis; neuroinflamation; acupuncture; neuroprotection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

Parkinson’s disease occurs as a result of decreased dopaminergic cells in the substantia nigra. The mechanism behind this decrease in dopaminergic cells remains unknown. About 1% of the population over 60 years of age suffer from Parkinson's disease, and the number of patients with Parkinson’s disease is rapidly increasing with the increase in life expectancy. Treatment strategies for Parkinson’s disease have increased in various ways over the past few years. In addition to drugs, surgery, rehabilitation, and other conventional therapies, many options are becoming a reality, including cell therapy and neurotrophic agents. This Special Issue of Biomedicines aims to investigate the novel mechanisms involved in Parkinson’s disease and further develop novel therapeutic strategies. Original articles and reviews are welcome for publication on the topic.

Dr. Sujung Yeo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parkinson’s disease
  • alpha-synuclein
  • dopaminergic neuron
  • pathology
  • therapy
  • neurodegeneration
  • neuroprotection

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Published Papers (1 paper)

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9 pages, 610 KiB  
Case Report
Dropped Head Syndrome: The Importance of Neurophysiology in Distinguishing Myasthenia Gravis from Parkinson’s Disease
by Marilena Mangiardi, Alessandro Magliozzi, Carlo Colosimo and Luca Marsili
Biomedicines 2024, 12(8), 1833; https://doi.org/10.3390/biomedicines12081833 - 12 Aug 2024
Cited by 1 | Viewed by 1864
Abstract
Dropped head syndrome (DHS) is characterized by severe forward flexion of the cervical spine due to an imbalance in neck muscle tone. This condition can be linked to various neuromuscular diseases, including myasthenia gravis (MG). On the other hand, Parkinson’s disease (PD) patients [...] Read more.
Dropped head syndrome (DHS) is characterized by severe forward flexion of the cervical spine due to an imbalance in neck muscle tone. This condition can be linked to various neuromuscular diseases, including myasthenia gravis (MG). On the other hand, Parkinson’s disease (PD) patients may show a clinically indistinguishable picture named antecollis, which is caused by increased axial tone, but without muscle weakness. Differentiating between DHS and antecollis is crucial due to their distinct treatment requirements. We present the case of a 71-year-old White male with a one-month history of severe neck flexion, mild dysphagia, and dysphonia. His medical history included diabetes mellitus, coronary artery disease, arterial hypertension, and mild cervical spondylosis. Neurological examination revealed features of Parkinsonism, including hypomimia, asymmetric rigidity, and reduced arm swing. There was significant weakness in his neck extensor muscles, with no signs of ptosis or diplopia. Brain/spine MRI scans were unremarkable, but electromyography showed a reduced compound muscle action potentials amplitude in repetitive nerve stimulation, consistent with MG. High-titer acetylcholine receptor antibodies confirmed the diagnosis. Treatment with pyridostigmine (60 to 120 mg/day) and plasma exchange (daily, for five consecutive days) improved the patient’s general condition and neck posture. Concurrently, the patient was diagnosed with PD based on established clinical criteria and improved with carbidopa/levodopa therapy (up to 150/600 mg/daily). This case highlights the rare co-occurrence of MG and PD, emphasizing the need for thorough clinical, neurophysiological, and laboratory evaluations in complex DHS presentations. Managing MG’s life-threatening aspects and addressing PD symptoms requires a tailored approach, showcasing the critical role of neurophysiology in accurate diagnosis and effective treatment. Full article
(This article belongs to the Special Issue Parkinson’s Disease: From Pathophysiology to Novel Therapeutic Approaches—Second Edition)
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