The Role of Oxidative Stress in Metabolic Syndrome
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 40
Special Issue Editor
Interests: metabolic syndrome; insulin resistance; obesity; tyep-2 diabetes; metabolic inflammation; chrononutrition; molecular nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In a normal cell, free radicals produced in a controlled manner play critical physiological roles in cell division, immunity, autophagy, and stress response. Uncontrolled intracellular oxidative stresses contribute to chronic inflammatory diseases, including diabetes, cancers, and neurodegenerative diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial transcription factor required for handling oxidative stress and subsequent triggering of cytoprotective mechanisms. The Kelch-like ECH-associated protein 1 (Keap1) that sequesters Nrf2 in the cytoplasm is an extensively studied mechanism regulating Nrf2 activity within the cell. However, the Keap1-independent mechanism regulating Nrf2 activities in sensing reactive oxidants has also been reported.
Dysregulation of Nrf2 activity shifts the balance towards pro-oxidative stress that triggers cascades of downstream processes. Understanding the convergence of various cellular stimuli to Nrf2 activity that subsequently leads to the divergence of downstream molecular processes is crucial for managing oxidative stress-related diseases. Nutritional and pharmacological bioactives targeting Nrf2 activity could be highly effective in neutralizing the oxidative damage caused by various endogenous and exogenous oxidative stressors.
This Special Issue of Biomedicines will showcase original research on oxidative stress mechanisms in metabolic syndrome in the context of chronic human disease models.
Topics of interest for this Special Issue include, but are not limited to, the following:
- Cellular inducers and inhibitors of Nrf2 activities and the sensing mechanism underlying cellular oxidative stress;
- Pharmaceutical, nutritional bioactives as novel antioxidants that modulate Nrf2 activities via Keap1-dependent and/or -independent pathways;
- Role of microbes/microbial metabolites on oxidative stress and human health;
- Nrf2 pathways in models of chronic inflammatory diseases;
- Effect of developmental stage/ageing on oxidative stress and human health;
- Downstream gene targets and regulatory mechanisms associated with Nrf2-mediated antioxidant activity.
In addition, reviews of articles on pharmacological and nutritional approaches that work through oxidative pathways in chronic inflammatory diseases are also welcome.
Dr. Bojlul Bahar
Guest Editor
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Keywords
- free radical
- oxidative stress
- ROS
- NRF2
- Keap1
- metabolic syndrome
- chronic inflammation
- cardiovascular disease
- obesity
- diabetes
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