Antioxidant and Anti-Inflammatory Agents in Chronic Liver Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2024

Special Issue Editor

1. Department of Surgery, University of Missouri, Columbia, MO 65212, USA
2. NextGen Precision Health Institute, University of Missouri, Columbia, MO 65212, USA
3. Harry S. Truman Memorial VA Hospital, Columbia, MO 65201, USA
Interests: chronic liver disease; non-alcoholic fatty liver disease; hepatocellular carcinoma; inflammation; oxidative stress; natural products; treatment; anticancer peptides
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Special Issue Information

Dear Colleague,

Chronic liver diseases (CLD) include alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), chronic viral infection, autoimmune hepatitis, etc., which may lead to liver fibrosis, cirrhosis, and cancer. Currently, there are no effective treatments for ALD-induced liver cancer. Liver inflammation, oxidative stress, and cell death are commonly associated with the progression of CLD. Recent studies have shown that anti-inflammatory and antioxidant agents are promising therapies against CLD. In addition, metabolic dysfunctions such as lipid accumulation and insulin resistance are commonly associated with CLD-to-cancer progression, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Therefore, it is essential to understand the underlying molecular and metabolic signaling pathways involved in the pathogenesis of CLD and target these pathways to develop therapeutic strategies to ameliorate CLD. This Special Issue, entitled “Antioxidant and Anti-Inflammatory Agents in Chronic Liver Diseases”, aims to provide a comprehensive overview of the most recent advances in this field and explore the current options and future research directions for CLD studies.

Dr. Ming Yang
Guest Editor

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Keywords

  • chronic liver disease
  • non-alcoholic fatty liver disease
  • alcoholic liver disease
  • liver inflammation
  • oxidative stress
  • liver fibrosis
  • hepatocellular carcinoma
  • cholangiocarcinoma

Published Papers (1 paper)

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Review

15 pages, 1051 KiB  
Review
The Roles of Myeloid-Derived Suppressor Cells in Liver Disease
by Chunye Zhang, Yuxiang Sui, Shuai Liu and Ming Yang
Biomedicines 2024, 12(2), 299; https://doi.org/10.3390/biomedicines12020299 - 27 Jan 2024
Cited by 2 | Viewed by 1783
Abstract
Liver disease-related mortality is a major cause of death worldwide. Hepatic innate and adaptive immune cells play diverse roles in liver homeostasis and disease. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells. MDSCs can be broadly divided into monocytic [...] Read more.
Liver disease-related mortality is a major cause of death worldwide. Hepatic innate and adaptive immune cells play diverse roles in liver homeostasis and disease. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells. MDSCs can be broadly divided into monocytic MDSCs and polymorphonuclear or granulocytic MDSCs, and they functionally interact with both liver parenchymal and nonparenchymal cells, such as hepatocytes and regulatory T cells, to impact liver disease progression. The infiltration and activation of MDSCs in liver disease can be regulated by inflammatory chemokines and cytokines, tumor-associated fibroblasts, epigenetic regulation factors, and gut microbiota during liver injury and cancer. Given the pivotal roles of MDSCs in advanced liver diseases, they can be targeted to treat primary and metastatic liver cancer, liver generation, alcoholic and nonalcoholic liver disease, and autoimmune hepatitis. Currently, several treatments such as the antioxidant and anti-inflammatory agent berberine are under preclinical and clinical investigation to evaluate their therapeutic efficacy on liver disease and their effect on MDSC infiltration and function. Phenotypic alteration of MDSCs in different liver diseases that are in a model-dependent manner and lack special markers for distinct MDSCs are challenges for targeting MDSCs to treat liver disease. Multi-omics study is an option to uncover the features of disease-specific MDSCs and potential gene or protein targets for liver disease treatment. In summary, MDSCs play important roles in the pathogenesis and progression of liver disease by regulating both intrahepatic innate and adaptive immune responses. Full article
(This article belongs to the Special Issue Antioxidant and Anti-Inflammatory Agents in Chronic Liver Diseases)
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