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Biomedicines
Special Issues
Tendinopathy and Myopathy: From Molecular Basis to Therapy
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Tendinopathy and Myopathy: From Molecular Basis to Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1319

Special Issue Editors

Dr. Simon Fuk-Tan Tang

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Guest Editor
1. Department of Physical Medicine and Rehabilitation, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan 333423, Taiwan
2. Department of Physical Medicine and Rehabilitation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan.
Interests: tendinopathy; myopathy
Dr. Carl Pai Chu Chen

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Guest Editor
Chang Gung Memorial Hospital, Linkou, Taoyuan City, Guishan Township, Taiwan
Interests: aging proteomics; disease proteomics

Special Issue Information

Dear Colleagues,

Tendinopathy and myopathy are prevalent musculoskeletal disorders affecting a significant number of individuals. New developments in comprehending tendinopathy and myopathy emphasize an increasing acknowledgment of various biomarkers, microRNAs, lncRNAs, and cellular reactions implicated in their development. Advanced technologies now allow for quantitative assessments of tissue vascularity, echogenicity, and elasticity, providing detailed and precise data that enhance our understanding of various disease processes. Furthermore, upcoming therapeutic approaches encompass stem cells, exosomes, biomaterials, and nanomaterials. This Special Issue titled “Tendinopathy and Myopathy: From Molecular Basis to Therapy” highlights the progress in the pathogenesis, diagnosis, and treatment of tendinopathies and myopathies. We invite experts worldwide to submit their latest research on this topic. Original articles and reviews are all equally welcomed contributions.

Dr. Simon Fuk-Tan Tang
Dr. Carl Pai Chu Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • musculoskeletal disorder
  • tendinopathy
  • myopathy

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Published Papers (2 papers)

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15 pages, 2590 KiB  
Article
Evaluating the Effectiveness of Ultrasound-Guided Subacromial-Subdeltoid Bursa and Coracohumeral Ligament Corticosteroid Injections With and Without Physiotherapy in Adhesive Capsulitis Treatment
by Chu-Wen Tang, Ting-Yu Lin, Peng-Chieh Shen and Fuk-Tan Tang
Biomedicines 2024, 12(12), 2668; https://doi.org/10.3390/biomedicines12122668 - 22 Nov 2024
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Abstract
Background: The objective of this study was to investigate the effect of ultrasound-guided corticosteroid injection to the subacromial-subdeltoid bursa (SSB) and coracohumeral ligament (CHL) in treating adhesive capsulitis, with a particular focus on evaluating the potential benefits of regular electrotherapy and conventional [...] Read more.
Background: The objective of this study was to investigate the effect of ultrasound-guided corticosteroid injection to the subacromial-subdeltoid bursa (SSB) and coracohumeral ligament (CHL) in treating adhesive capsulitis, with a particular focus on evaluating the potential benefits of regular electrotherapy and conventional rehabilitation exercises. Methods: A total of 29 patients with unilateral shoulder pain and restricted shoulder range of motion (ROM) were included. Corticosteroids were delivered to the subacromial-subdeltoid bursa (SSB) and coracohumeral ligament (CHL) through a single percutaneous injection. Group 1 consisted of 18 patients who received injections only, while Group 2 comprised 11 patients who received injections in combination with regular physiotherapy. Shoulder Pain and Disability Index (SPADI) scores and ROM were assessed before the injection, and again at 4, 8, and 12 weeks following the intervention. A multivariate mixed-effects model with repeated measurements was conducted for the variables. Results: Electrotherapy and traditional rehabilitation exercises did not enhance the effectiveness of this injection approach. Pain, upper extremity function, and ROM in all planes were all significantly improved with a corticosteroid injection to the CHL and SSB. Conclusions: Physiotherapy did not offer additional benefits when combined with ultrasound-guided corticosteroid injection to the CHL and SSB. The injection alone significantly improved pain, disability, and ROM in patients with adhesive capsulitis. Further research is required to optimize current physiotherapy with electrotherapy and traditional rehabilitation exercises after ultrasound-guided corticosteroid injections. Full article
(This article belongs to the Special Issue Tendinopathy and Myopathy: From Molecular Basis to Therapy)
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18 pages, 3242 KiB  
Systematic Review
Biological and Cellular Effects of Percutaneous Electrolysis: A Systematic Review
by Jacobo Rodríguez-Sanz, Sergi Rodríguez-Rodríguez, Carlos López-de-Celis, Miguel Malo-Urriés, Soledad Pérez-Amodio, Román Pérez-Antoñanzas, Sergio Borrella-Andrés, Isabel Albarova-Corral and Miguel Ángel Mateos-Timoneda
Biomedicines 2024, 12(12), 2818; https://doi.org/10.3390/biomedicines12122818 - 12 Dec 2024
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Abstract
Background: Percutaneous electrolysis is an invasive physical therapy technique that is receiving attention. The objective of this article is to evaluate the biological and cellular effects of percutaneous electrolysis and its influence on tissue healing processes. Methods. The search strategy performed [...] Read more.
Background: Percutaneous electrolysis is an invasive physical therapy technique that is receiving attention. The objective of this article is to evaluate the biological and cellular effects of percutaneous electrolysis and its influence on tissue healing processes. Methods. The search strategy performed in PubMed, Cochrane Library, and Web of Sciences databases resulted in a total of 25 studies. Once inclusion and exclusion criteria were applied, seven studies were finally included in this systematic review. The biological effects of percutaneous electrolysis were evaluated and grouped into pro-inflammatory and anti-inflammatory effects, cell death, and extracellular matrix and tissue remodeling effects. Results. Percutaneous electrolysis generates a significant pro-inflammatory increase in the chronic tendon condition of IL1β-6-18-1α-1rn, NLRP3, and M1 polymorphonuclear cells and increased expression of COX2, TNFα, Cxcl10, and TGFβ1 during the first 7 days. This inflammation is regulated as of day 13. A significant increase in cell death markers, such as LDH, Yo-Pro, cytochrome C, and Smac/Diablo markers, was observed during the first 7 days. Finally, a significant increase in markers Mmp9, VEGF, VEGFR, PPAR-γ/tubulin, and COL-I was observed in the extracellular matrix and tissue remodeling, and a decrease in COL-III was observed during the first 7 days. In the acute inflammatory injury condition, an increase in anti-inflammatory markers, such as IL-10-13, CCL1, and IkB, and a significant decrease in pro-inflammatory cytokines, such as IL-6-1β, CCL3-4-5, CCR5-8, NFkB, and TNFα, were observed during the first 7 days. Finally, a significant increase in VEGF, VEGFR, and PPAR-γ/tubulin markers in the extracellular matrix and tissue remodeling was observed for this condition during the first 7 days. Conclusions. Percutaneous electrolysis generates a controlled local pro-inflammatory effect in chronic conditions and regulates inflammation in inflammatory injuries (during the first 7 days). Electrolysis has short-term effects (0–7 days post) of cell death and controlled extracellular matrix destruction. Additionally, it facilitates subsequent healing by improving extracellular matrix synthesis starting from 7 days after application. Full article
(This article belongs to the Special Issue Tendinopathy and Myopathy: From Molecular Basis to Therapy)
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