State-of-the-Art Neonatal Medicine in Japan

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 503

Special Issue Editor


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Guest Editor
Department of Pediatrics, Saitama Medical center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan
Interests: bronchopulmonary dysplasia; patent ductus arteriosus; preterm infants
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Special Issue Information

Dear Colleagues,

In conjunction with the significant advancements in perinatal and neonatal medicine, there has been a notable decline in global rates of neonatal and infant mortality. Japan boasts one of the lowest rates of neonatal and infant mortality in the world. In particular, the results for extremely premature babies and periviable babies born at 22–23 weeks of gestation are exemplary. Japanese neonatal medicine and neonatology have recently gained global recognition. In light of these developments, we have created this Special Issue, which will focus on the cutting-edge neonatal medicine currently being carried out in Japan.

We invite all authors who are actively involved in neonatal medicine in Japan to contribute to this Special Issue. We welcome original research articles and reviews on the most pressing topics related to identifying and introducing new medicines and cutting-edge methodological advances.

Dr. Fumihiko Namba
Guest Editor

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Keywords

  • mesenchymal stromal cells
  • artificial placenta
  • therapeutic gasses
  • animal models
  • off-label drug use

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Published Papers (1 paper)

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7 pages, 878 KiB  
Perspective
Shifting Paradigms in Bronchopulmonary Dysplasia: From Treatment to Etiology/Pathophysiology-Based Classification
by Fumihiko Namba and Hidehiko Nakanishi
Biomedicines 2025, 13(4), 985; https://doi.org/10.3390/biomedicines13040985 - 17 Apr 2025
Viewed by 139
Abstract
Bronchopulmonary dysplasia (BPD) is a severe chronic respiratory disease linked to preterm births. A scoping review was performed to identify risk factors for moderate and severe BPD to develop an evidence-based, early prognostic, globally recognized, and etiology/pathophysiology-based classification. The findings were then validated [...] Read more.
Bronchopulmonary dysplasia (BPD) is a severe chronic respiratory disease linked to preterm births. A scoping review was performed to identify risk factors for moderate and severe BPD to develop an evidence-based, early prognostic, globally recognized, and etiology/pathophysiology-based classification. The findings were then validated against a Japanese national database, the Neonatal Research Network Japan. After identifying histological chorioamnionitis, bubbly/cystic appearance on chest X-ray, and small-for-gestational-age infants as risk factors for severe BPD, BPD was divided into nine categories based on the presence or absence of these three risk factors. After consensus was reached using the Delphi method, public comments were requested, and the classification of BPD was finalized. This perspective introduces the new etiology/pathophysiology-based BPD classification, which should be used in research to better understand the respiratory prognosis and pathophysiology of BPD. Full article
(This article belongs to the Special Issue State-of-the-Art Neonatal Medicine in Japan)
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